Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | WDR5 | P61964 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | ALPI | P09923 | 1/20 | 0.32 |
| ▸ | ALPG | P10696 | 1/20 | 0.32 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10651361 | 0.80 | KMT2A (0.38) | LMNAL3MBTL1KMT2APOLBMEN1 | |
| SCHEMBL10648091 | 0.77 | PDE3B (0.43) | POLBMAPTPDE3BPDE3A | |
| SCHEMBL10650510 | 0.72 | PDE3B (0.48) | LMNAL3MBTL1HTR1AHTR2CMAPT | |
| SCHEMBL27568498 | 0.66 | CYP1A2 (0.43) | LMNAKMT2APOLBMEN1PDE3B | |
| SCHEMBL31270697 | 0.66 | LMNA (0.74) | LMNAL3MBTL1KMT2APOLBHTR1A | |
| SCHEMBL11420217 | 0.66 | LMNA (0.52) | LMNAL3MBTL1KMT2AMEN1ALDH1A1 | |
| SCHEMBL7280249 | 0.65 | LMNA (0.56) | LMNAKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL10650257 | 0.65 | PDE3B (0.62) | LMNAMAPTPDE3BPDE3A | |
| SCHEMBL10724349 | 0.64 | LMNA (0.39) | LMNAL3MBTL1KMT2AGLSALDH1A1 | |
| SCHEMBL81625 | 0.62 | LMNA (0.63) | LMNAL3MBTL1KMT2APOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |