Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10648512 | 0.99 | TBXAS1 (0.44) | TBXAS1PDE3BPDE3AHMOX1CYP11B1 | |
| SCHEMBL10651613 | 0.97 | PDE3B (0.43) | TBXAS1PDE3BPDE3ACYP11B1CYP11B2 | |
| SCHEMBL11115116 | 0.92 | PDE3B (0.44) | TBXAS1PDE3BPDE3ACYP11B1CYP11B2 | |
| SCHEMBL10645457 | 0.84 | CYP11B1 (0.56) | TBXAS1PDE3BPDE3ACYP11B1CYP11B2 | |
| SCHEMBL10646129 | 0.78 | HRH3 (0.53) | — | |
| SCHEMBL10650982 | 0.77 | HRH3 (0.52) | — | |
| SCHEMBL10645518 | 0.75 | PDE3B (0.43) | TBXAS1PDE3BPDE3AHMOX1CYP11B1 | |
| SCHEMBL10924625 | 0.74 | PDE3B (0.42) | TBXAS1PDE3BPDE3AHMOX1 | |
| SCHEMBL10922175 | 0.74 | PDE3B (0.42) | TBXAS1PDE3BPDE3AHMOX1 | |
| SCHEMBL10926117 | 0.74 | PDE3B (0.42) | TBXAS1PDE3BPDE3AHMOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |