Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 3/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10646129 | 0.99 | HRH3 (0.53) | HRH3SIGMAR1PARP1HRH1HRH4 | |
| SCHEMBL10646693 | 0.95 | HRH3 (0.54) | HRH3PARP1 | |
| SCHEMBL10650493 | 0.90 | HRH3 (0.50) | HRH3 | |
| SCHEMBL10649218 | 0.77 | TBXAS1 (0.42) | — | |
| SCHEMBL10650307 | 0.74 | HRH3 (0.52) | HRH3SIGMAR1HRH1HRH4 | |
| SCHEMBL10651613 | 0.73 | PDE3B (0.43) | — | |
| SCHEMBL10646470 | 0.73 | HRH3 (0.53) | HRH3SIGMAR1HRH1HRH4 | |
| SCHEMBL11119254 | 0.69 | HRH3 (0.54) | HRH3SIGMAR1PARP1 | |
| SCHEMBL10648317 | 0.69 | CYP1A2 (0.39) | — | |
| SCHEMBL1373074 | 0.68 | HRH3 (1.00) | HRH3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |