Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 15/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 15/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 15/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 15/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 15/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 15/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 15/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 14/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 14/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 14/20 | 0.64 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.48 |
| ▸ | CPN1 | P15169 | 1/20 | 0.48 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1064956 | 0.99 | HDAC1 (0.67) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL1058606 | 0.86 | HDAC8 (0.54) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL1064490 | 0.85 | HDAC8 (0.56) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL1064471 | 0.84 | RAB9A (0.52) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL1064952 | 0.79 | HDAC1 (1.00) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL1064957 | 0.79 | HDAC1 (1.00) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL1063952 | 0.79 | HDAC1 (0.58) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL1060811 | 0.78 | HDAC1 (0.60) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL1064045 | 0.78 | L3MBTL1 (0.59) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL466227 | 0.77 | HDAC2 (0.64) | HDAC4HDAC1HDAC7HDAC11HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9957225-B2 | Treatment of friedreich's ataxia using histone deacetylase inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2018-05-01 | — | — | US | disclosed |
| US-20150080472-A1 | TREATMENT OF FRIEDREICH'S ATAXIA USING HISTONE DEACETYLASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE | 2015-03-19 | — | — | US | disclosed |
| US-8835502-B2 | Treatment of friedreich's ataxia using histone deacetylase inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-09-16 | — | — | US | disclosed |
| US-20130210918-A1 | TREATMENT OF FRIEDREICH'S ATAXIA USING HISTONE DEACETYLASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-08-15 | — | — | US | disclosed |
| US-20110021562-A1 | TREATMENT OF FRIEDREICH'S ATAXIA USING HISTONE DEACETYLASE INHIBITORS | THE SCRIPPS RESEARCH INSTUTE (US) | 2011-01-27 | — | — | US | disclosed |
| US-20070219244-A1 | Histone deacetylase inhibitors as therapeutics for neurological diseases | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021562-A1 | TREATMENT OF FRIEDREICH'S ATAXIA USING HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC4, HDAC6 | HDAC4 2/4885HDAC1 1/4885HDAC7 10/4885 |
| US-20130210918-A1 | TREATMENT OF FRIEDREICH'S ATAXIA USING HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC4, HDAC6 | HDAC4 2/4885HDAC1 1/4885HDAC7 10/4885 |
| US-20150080472-A1 | TREATMENT OF FRIEDREICH'S ATAXIA USING HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC4, HDAC6 | HDAC4 2/4885HDAC1 1/4885HDAC7 10/4885 |
| US-20070219244-A1 | Histone deacetylase inhibitors as therapeutics for neurological diseases | HDAC5, HDAC1, HDAC6 | HDAC4 5/4885HDAC1 2/4885HDAC7 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.