SCHEMBL466227

SCHEMBL466227

NC(=O)C(O)CCCCCC(=O)Nc1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC2 Q92769 15/20 0.64
HDAC8 Q9BY41 18/20 0.61
HDAC6 Q9UBN7 17/20 0.61
HDAC1 Q13547 16/20 0.61
HDAC3 O15379 16/20 0.61
HDAC4 P56524 14/20 0.61
HDAC7 Q8WUI4 14/20 0.61
HDAC11 Q96DB2 14/20 0.61
HDAC9 Q9UKV0 14/20 0.61
HDAC5 Q9UQL6 14/20 0.61
HDAC10 Q969S8 13/20 0.61
NCOR2 Q9Y618 2/20 0.60
KDM4E B2RXH2 1/20 0.60
BRD4 O60885 1/20 0.60
NCOR1 O75376 1/20 0.60
NR1I2 O75469 1/20 0.60
EGFR P00533 1/20 0.60
CYP3A4 P08684 1/20 0.60
LTA4H P09960 1/20 0.60
NR0B1 P51843 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30345341 0.85 HDAC2 (0.47) HDAC2HDAC8HDAC6HDAC1HDAC3
SCHEMBL27770767 0.84 HDAC2 (0.80) HDAC2HDAC8HDAC6HDAC1HDAC3
SCHEMBL20487166 0.84 HDAC4 (0.66) HDAC2HDAC8HDAC6HDAC1HDAC3
SCHEMBL1065527 0.82 HDAC6 (0.74) HDAC2HDAC8HDAC6HDAC1HDAC3
SCHEMBL1433994 0.82 HDAC6 (0.74) HDAC2HDAC8HDAC6HDAC1HDAC3
SCHEMBL28784814 0.82 HDAC2 (0.77) HDAC2HDAC8HDAC6HDAC1HDAC3
Hydroxyamine SCHEMBL1268824 0.82 HDAC6 (0.79) HDAC2HDAC8HDAC6HDAC1HDAC3
SCHEMBL6669511 0.82 HDAC4 (0.85) HDAC2HDAC8HDAC6HDAC1HDAC3
SCHEMBL137348 0.82 HDAC4 (0.85) HDAC2HDAC8HDAC6HDAC1HDAC3
SCHEMBL1065393 0.82 HDAC4 (0.85) HDAC2HDAC8HDAC6HDAC1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190374525-A1 TREATMENT OF DIABETES AND ASSOCIATED METABOLIC CONDITIONS WITH EPIGENETIC MODULATORS TEMPLE OTORONGO LLC (US) 2019-12-12 US claimed
US-20240173320-A1 METHODS OF USING EHMT2 INHIBITORS IN IMMUNOTHERAPIES Epizyme, Inc. 2024-05-30 US disclosed
US-20240100079-A1 METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS IN THE INNER EAR OF ADULT MAMMALS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-03-28 US disclosed
US-11466252-B2 Expansion and differentiation of inner ear supporting cells and methods of use thereof MASSACHUSETTS EYE AND EAR INFIRMARY (US) 2022-10-11 US disclosed
US-20220192984-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING OTIC THERAPEUTIC AGENTS AND RELATED METHODS Frequency Therapeutics, Inc. 2022-06-23 US disclosed
US-20210213014-A1 METHODS OF USING EHMT2 INHIBITORS IN IMMUNOTHERAPIES Epizyme, Inc. 2021-07-15 US disclosed
WO-2020018848-A1 METHODS OF CULTURING AND/OR EXPANDING STEM CELLS AND/OR LINEAGE COMMITTED PROGENITOR CELLS USING AMIDO COMPOUNDS IDEAYA BIOSCIENCES, INC. (US) 2020-01-23 WO disclosed
US-20190374525-A1 TREATMENT OF DIABETES AND ASSOCIATED METABOLIC CONDITIONS WITH EPIGENETIC MODULATORS TEMPLE OTORONGO LLC (US) 2019-12-12 US disclosed
US-20190010449-A1 Expansion and Differentiation of Inner Ear Supporting Cells and Methods of Use Thereof MASSACHUSETTS EYE AND EAR INFIRMARY 2019-01-10 US disclosed
WO-2018226939-A1 COMPOSITIONS AND METHODS OF TREATING AND/OR PREVENTING CANCER RANEDIS PHARMACEUTICALS, LLC (US) 2018-12-13 WO disclosed
EP-3191104-A1 METHODS FOR TREATING A DISEASE OR DISORDER USING ORAL FORMULATIONS OF CYTIDINE ANALOGS IN COMBINATION WITH AN ANTI-PD1 OR ANTI-PDL1 MONOCLONAL ANTIBODY Celgene Corporation (US) 2017-07-19 EP disclosed
WO-2016040238-A1 METHODS FOR TREATING A DISEASE OR DISORDER USING ORAL FORMULATIONS OF CYTIDINE ANALOGS IN COMBINATION WITH AN ANTI-PD1 OR ANTI-PDL1 MONOCLONAL ANTIBODY CELGENE CORPORATION (US) 2016-03-17 WO disclosed
WO-2015195634-A1 METHODS FOR TREATING EPSTEIN-BARR VIRUS (EBV) ASSOCIATED CANCERS USING ORAL FORMULATIONS OF 5-AZACYTIDINE CELGNE CORPORATION (US) 2015-12-23 WO disclosed
WO-2014160698-A1 SOLID FORMS COMPRISING 4-AMINO-I-β-D-RIBOFURANOSYL-1,3,5-TRIAZIN-2(1H)-ONE AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF CELGENE CORPORATION (US) 2014-10-02 WO disclosed
EP-2405908-A1 PHARMACEUTICAL COMBINATIONS COMPRISING RDEA119/BAY 869766 FOR THE TREATMENT OF SPECIFIC CANCERS Ardea Biosciences, Inc. (US) 2012-01-18 EP disclosed
WO-2010105110-A1 PHARMACEUTICAL COMBINATIONS COMPRISING RDEA119/BAY 869766 FOR THE TREATMENT OF SPECIFIC CANCERS ARDEA BIOSCIENCES, INC. (US) 2010-09-16 WO disclosed
EP-1541549-A1 Tricyclic hydroxamate and benzaminde derivatives, compositions and methods Exonhit Therapeutics S.A. (FR) 2005-06-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240173320-A1 METHODS OF USING EHMT2 INHIBITORS IN IMMUNOTHERAPIES EHMT2, BHMT2, BHMT HDAC2 268/4885HDAC8 454/4885HDAC6 821/4885
US-20190374525-A1 TREATMENT OF DIABETES AND ASSOCIATED METABOLIC CONDITIONS WITH EPIGENETIC MODULATORS GPR119, SREBF1, SREBF2 HDAC2 23/4885HDAC8 37/4885HDAC6 386/4885
US-20220192984-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING OTIC THERAPEUTIC AGENTS AND RELATED METHODS OTC, EXOSC5, ENTPD5 HDAC2 2986/4885HDAC8 3334/4885HDAC6 1191/4885
US-20210213014-A1 METHODS OF USING EHMT2 INHIBITORS IN IMMUNOTHERAPIES EHMT2, BHMT2, BHMT HDAC2 268/4885HDAC8 454/4885HDAC6 821/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.