Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.71 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.71 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | PDE2A | O00408 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7280366 | 0.83 | PDE3B (1.00) | PDE3BPDE3APDE2ACYP1A2CYP3A4 | |
| SCHEMBL12596036 | 0.77 | PDE3B (0.64) | PDE3BPDE3APDE2ACYP1A2MEN1 | |
| SCHEMBL10353459 | 0.76 | CYP1A2 (0.74) | PDE3BPDE3ACYP1A2MEN1TSHR | |
| SCHEMBL10650257 | 0.75 | PDE3B (0.62) | PDE3BPDE3AIDO1PDE2ACYP1A2 | |
| SCHEMBL10553489 | 0.75 | PDE3B (0.69) | PDE3BPDE3APDE2ACYP1A2CYP3A4 | |
| SCHEMBL12648802 | 0.74 | PDE3B (0.60) | PDE3BPDE3APDE2ACYP1A2CYP3A4 | |
| SCHEMBL4865755 | 0.74 | MEN1 (0.71) | PDE3BPDE3AIDO1MAOAMAOB | |
| SCHEMBL14489499 | 0.73 | IDO1 (0.75) | PDE3BPDE3AIDO1CYP3A4MEN1 | |
| SCHEMBL15021516 | 0.72 | IDO1 (0.60) | PDE3BPDE3AIDO1CYP1A2MAOA | |
| SCHEMBL7298232 | 0.70 | CYP1A2 (0.65) | PDE3BPDE3ACYP1A2MEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4734415-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1988-03-29 | — | — | US | claimed |
| EP-0075436-A1 | Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted)phenyl-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1983-03-30 | — | — | EP | claimed |
| US-4734415-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1988-03-29 | — | — | US | disclosed |
| EP-0075436-A1 | Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted)phenyl-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1983-03-30 | — | — | EP | disclosed |