Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3452908 | 0.77 | LMNA (0.80) | PDE3BPDE3ALMNAMEN1KMT2A | |
| SCHEMBL7277959 | 0.75 | PDE3B (0.68) | PDE3BPDE3ALMNAMEN1KMT2A | |
| SCHEMBL28108762 | 0.75 | KDM4E (0.64) | CYP1A2KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL31553322 | 0.74 | PIM1 (0.40) | PDE3BPDE3AMEN1KMT2ACYP1A2 | |
| SCHEMBL31553324 | 0.74 | PIM1 (0.40) | PDE3BPDE3AMEN1KMT2ACYP1A2 | |
| SCHEMBL10651151 | 0.74 | PDE3B (0.37) | PDE3BPDE3ALMNAMEN1KMT2A | |
| SCHEMBL7280366 | 0.73 | PDE3B (1.00) | PDE3BPDE3ALMNAMEN1KMT2A | |
| SCHEMBL27905069 | 0.73 | SMN1; SMN2 (0.72) | CYP1A2KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7279874 | 0.72 | PDE3A (0.68) | PDE3BPDE3ALMNAMEN1KMT2A | |
| SCHEMBL7319085 | 0.71 | PDE3B (0.67) | PDE3BPDE3ALMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4734415-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1988-03-29 | — | — | US | claimed |
| EP-0075436-A1 | Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted)phenyl-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1983-03-30 | — | — | EP | claimed |
| US-4734415-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1988-03-29 | — | — | US | disclosed |