Tyrosine

Tyrosine

SCHEMBL1065122

N[C@@H](Cc1ccc(O)cc1)C(=O)O.N[C@@H](Cc1ccccc1)C(=O)OC(=O)[C@@H](N)Cc1c[nH]c2ccccc12

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.68
KDM4E B2RXH2 3/20 0.68
MAPT P10636 3/20 0.68
LMNA P02545 2/20 0.68
TSHR P16473 2/20 0.68
BLM P54132 2/20 0.68
PMP22 Q01453 2/20 0.68
MEN1 O00255 2/20 0.68
MPO P05164 1/20 0.68
HIF1A Q16665 1/20 0.68
ALDH1A1 P00352 1/20 0.58
CYP3A4 P08684 1/20 0.58
HTR1A P08908 1/20 0.58
ADORA3 P0DMS8 1/20 0.58
ALOX15 P16050 1/20 0.58
NFKB1 P19838 1/20 0.58
HTR2A P28223 1/20 0.58
HTR2C P28335 1/20 0.58
SLC6A4 P31645 1/20 0.58
HTR7 P34969 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10359013 0.94 TACR1 (0.62) KMT2AKDM4EMAPTLMNATSHR
SCHEMBL243575 0.94 TACR1 (0.62) KMT2AKDM4EMAPTLMNATSHR
Tyrosine SCHEMBL9449484 0.94 KDM4E (0.63) KMT2AKDM4EMAPTLMNATSHR
Tryptophan SCHEMBL325026 0.93 KMT2A (0.78) KMT2AKDM4EMAPTLMNATSHR
Dl-Tryptophan SCHEMBL27561249 0.93 KMT2A (0.78) KMT2AKDM4EMAPTLMNATSHR
Dl-Tryptophan SCHEMBL152717 0.93 KMT2A (0.78) KMT2AKDM4EMAPTLMNATSHR
Tryptophan SCHEMBL15168746 0.92 KMT2A (0.80) KMT2AKDM4EMAPTLMNATSHR
Tryptophan SCHEMBL243574 0.92 KMT2A (0.80) KMT2AKDM4EMAPTLMNATSHR
D-Tryptophan SCHEMBL10359012 0.92 KMT2A (0.80) KMT2AKDM4EMAPTLMNATSHR
Tryptophan SCHEMBL6032938 0.92 KMT2A (0.80) KMT2AKDM4EMAPTLMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 154 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0868535-B9 METHODS AND COMPOSITIONS FOR DETERMINING THE SEQUENCE OF NUCLEIC ACID MOLECULES QIAGEN GENOMICS INC (US) 2007-05-09 EP claimed
EP-0868535-B2 METHODS AND COMPOSITIONS FOR DETERMINING THE SEQUENCE OF NUCLEIC ACID MOLECULES QIAGEN GENOMICS INC (US) 2006-01-04 EP claimed
EP-3565837-B1 COMBINED TREATMENT WITH NETRIN-1 INTERFERING DRUG AND IMMUNE CHECKPOINT INHIBITORS DRUGS NETRIS PHARMA (FR) 2024-04-10 EP disclosed
WO-2024049682-A2 PROTEINS FOR CROSS-LINKING BIOPOLYMERS ZYMERGEN INC. (US) 2024-03-07 WO disclosed
CN-110291105-B Combination therapy of guide-1 interfering drugs and immune checkpoint inhibitor drugs 奈特里斯药物公司 2024-03-01 CN disclosed
WO-2023186968-A1 NOVEL MCL-1 INHIBITOR AND COMBINATION OF MCL-1 AND A BH3 MIMETIC, SUCH AS A BCL-2 INHIBITOR NETRIS PHARMA (FR) 2023-10-05 WO disclosed
WO-2023180276-A1 ANTI-NETRIN-1 ANTIBODY AGAINST ARTHRITIS-ASSOCIATED PAIN NETRIS PHARMA (FR) 2023-09-28 WO disclosed
US-20230303676-A1 Anti-netrin-1 antibody to treat liver inflammation NETRIS PHARMA (FR) 2023-09-28 US disclosed
EP-4249509-A1 ANTI-NETRIN-1 ANTIBODY AGAINST ARTHRITIS-ASSOCIATED PAIN Netris Pharma (FR) 2023-09-27 EP disclosed
EP-4245772-A1 ANTI-NETRIN-1 ANTIBODY TO TREAT LIVER INFLAMMATION Netris Pharma (FR) 2023-09-20 EP disclosed
WO-2023102551-A2 FUNGAL PROTEASES, TREATED COMPOSITIONS, AND USES THEREOF SHARED-X LLC (US) 2023-06-08 WO disclosed
EP-1666604-A1 Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof The Scripps Research Institute (US) 2006-06-07 EP disclosed
WO-2006018204-A1 MODIFIED VITAMIN K DEPENDENT POLYPEPTIDES ZLB BEHRING GMBH (DE) 2006-02-23 WO disclosed
US-20050271686-A1 HIV vaccine THE UNIVERSITY OF WESTERN ONTARIO (CA) 2005-12-08 US disclosed
US-20040185537-A1 Novel fructosyltransferases NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) 2004-09-23 US disclosed
EP-1244689-A2 CYTOKINE POLYPEPTIDES AND NUCLEIC ACIDS Maxygen, Inc. (US) 2002-10-02 EP disclosed
WO-2001098454-A2 HUMAN DNA SEQUENCES GERMAN HUMAN GENOME PROJECT (US) 2001-12-27 WO disclosed
WO-2001040257-A2 MODIFIED IL-12 SUBUNITS AND NUCLEIC ACIDS ENCODING THEM MAXYGEN, INC. (US) 2001-06-07 WO disclosed
US-4650661-A OF RENIN, OLIGOPEPTIDE HYPOTENSIVES AKTIEBOLAGET HASSLE 1987-03-17 US disclosed
US-4609643-A OLIGOPEPTIDE ANALOG, HYPOTENSIVE AKTIEBOLAGET HASSLE (SE) 1986-09-02 US disclosed