Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10651275 | 0.90 | CYP11B1 (0.45) | CYP11B1CYP11B2ALOX5USP7KDM4E | |
| SCHEMBL10649894 | 0.76 | CYP1A2 (0.58) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL11121622 | 0.76 | CA12 (0.49) | CYP11B1CYP11B2ALOX5USP7KDM4E | |
| Hydrochloric Acid SCHEMBL11121633 | 0.76 | CA12 (0.49) | CYP11B1CYP11B2ALOX5USP7KDM4E | |
| SCHEMBL9375701 | 0.76 | DNMT1 (0.35) | CYP11B1CYP11B2USP7KDM4EALDH1A1 | |
| SCHEMBL10651166 | 0.74 | CYP11B1 (0.50) | CYP11B1CYP11B2ALOX5USP7KDM4E | |
| SCHEMBL10649864 | 0.74 | CYP11B1 (0.52) | CYP11B1CYP11B2ALOX5USP7KDM4E | |
| SCHEMBL25457211 | 0.73 | RAB9A (0.53) | KDM4EALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL10649858 | 0.73 | NOS1 (0.51) | CYP11B1CYP11B2ALOX5USP7KDM4E | |
| SCHEMBL10653023 | 0.73 | PDE3B (0.46) | CYP11B1CYP11B2ALOX5USP7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0120589-B1 | IMIDAZO-HETEROCYCLIC COMPOUNDS, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |
| US-4621084-A | CARDIOTONIC, ANTIULCER | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-11-04 | — | — | US | disclosed |
| EP-0120589-A1 | Imidazo-heterocyclic compounds, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-10-03 | — | — | EP | disclosed |