Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL313922 | 0.95 | MAPT (0.58) | MAPTKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL313315 | 0.91 | HSPB1 (0.50) | MAPTKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4921528 | 0.86 | MAPT (0.49) | MAPTKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8755108 | 0.79 | L3MBTL1 (0.41) | KMT2ASMN1; SMN2ALDH1A1MEN1MAPK1 | |
| SCHEMBL74124 | 0.79 | ALDH1A1 (0.56) | MAPTKMT2AALDH1A1POLBIDO1 | |
| SCHEMBL8746689 | 0.78 | ALDH1A1 (0.54) | MAPTKMT2AALDH1A1POLBIDO1 | |
| SCHEMBL8746687 | 0.78 | ALDH1A1 (0.64) | MAPTKMT2AALDH1A1POLBIDO1 | |
| SCHEMBL10828201 | 0.77 | KMT2A (0.49) | MAPTKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11310402 | 0.76 | MAPT (0.44) | MAPTKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9395356 | 0.76 | MAPT (0.57) | MAPTKMT2AALDH1A1POLBIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257391-A2 | 5-Substituted-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines | FISONS CORPORATION (US) | 1988-03-02 | — | — | EP | disclosed |
| US-4727156-A | 3-(Substituted phenyl)-3-(1H-imidazol-1-ylmethyl)-2-methyl-5-{[(substituted phenyl)thio]me}isoxazolidine derivatives | PENNWALT CORPORATION (US) | 1988-02-23 | — | — | US | disclosed |