Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.52 |
| ▸ | SCN1A | P35498 | 2/20 | 0.52 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.52 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22655275 | 0.84 | HSD17B3 (0.51) | LMNACYP1A2TSHRCYP2C19MAPT | |
| SCHEMBL9016067 | 0.84 | HSD17B3 (0.51) | LMNACYP1A2TSHRCYP2C19MAPT | |
| SCHEMBL6511114 | 0.83 | ALDH1A1 (0.46) | LMNACYP1A2CYP3A4TSHRCYP2C19 | |
| SCHEMBL27200589 | 0.83 | HTR7 (0.62) | LMNACYP1A2CYP3A4TSHRCYP2C19 | |
| SCHEMBL1535709 | 0.83 | CES2 (0.56) | LMNATSHRMAPTALDH1A1ESR1 | |
| SCHEMBL28852607 | 0.81 | ALDH1A1 (0.53) | LMNACYP1A2CYP3A4TSHRCYP2C19 | |
| SCHEMBL18587941 | 0.80 | L3MBTL1 (0.39) | LMNACYP1A2CYP3A4TSHRCYP2C19 | |
| SCHEMBL28102302 | 0.80 | TP53 (0.53) | TSHRMAPTALDH1A1 | |
| SCHEMBL27818527 | 0.80 | ALDH1A1 (0.47) | LMNACYP1A2TSHRCYP2C19MAPT | |
| SCHEMBL27818338 | 0.80 | L3MBTL1 (0.47) | LMNACYP1A2CYP3A4TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150937-B1 | DIHYDROPYRIDAZINONES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-09-14 | — | — | EP | disclosed |
| US-4654342-A | TREATMENT OF CONGESTIVE HEART FAILURE BRONCHODILATION | SMITH KLINE & FRENCH LABORATORIES LTD. (GB) | 1987-03-31 | — | — | US | disclosed |
| EP-0150937-A2 | Dihydropyridazinones | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-08-07 | — | — | EP | disclosed |
| WO-1985003076-A1 | DIHYDROPYRIDAZINONES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-07-18 | — | — | WO | disclosed |