Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10652053 | 0.80 | KMT2A (0.52) | KMT2ALMNAHTTMAPTTP53 | |
| SCHEMBL10653057 | 0.73 | KMT2A (0.67) | KMT2AMAPTTP53ALDH1A1POLB | |
| SCHEMBL11627091 | 0.72 | HCAR3 (0.43) | LMNAPOLBTDP1 | |
| SCHEMBL10571707 | 0.69 | KMT2A (0.55) | KMT2ALMNAHTTMAPTTP53 | |
| SCHEMBL6562303 | 0.68 | KMT2A (0.50) | KMT2ALMNAMAPTTP53ALDH1A1 | |
| SCHEMBL6563976 | 0.67 | KMT2A (0.52) | KMT2ALMNAMAPTTP53ALDH1A1 | |
| SCHEMBL9620470 | 0.65 | ALDH1A1 (0.54) | KMT2ALMNAHTTMAPTALDH1A1 | |
| SCHEMBL356201 | 0.65 | KMT2A (0.51) | KMT2ALMNAHTTMAPTALDH1A1 | |
| SCHEMBL425321 | 0.64 | CASP6 (0.60) | LMNAPOLB | |
| SCHEMBL17512440 | 0.64 | HCAR3 (0.62) | KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0197386-B1 | 2-(SUBSTITUTED SULFAMYL) DERIVATIVES OF 6-NITROBENZOIC ACID, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1988-11-02 | — | — | EP | claimed |