Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10652663 | 0.80 | KMT2A (0.44) | KMT2AMEN1POLBMAPTTP53 | |
| SCHEMBL10655216 | 0.80 | GFER (0.47) | KMT2AMEN1POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL9620470 | 0.79 | ALDH1A1 (0.54) | KMT2AMEN1POLBMAPTALDH1A1 | |
| SCHEMBL10653057 | 0.78 | KMT2A (0.67) | KMT2AMEN1POLBMAPTTP53 | |
| SCHEMBL4815935 | 0.75 | TDP1 (0.54) | KMT2AMEN1POLBMAPTALDH1A1 | |
| SCHEMBL6562303 | 0.73 | KMT2A (0.50) | KMT2AMEN1POLBMAPTTP53 | |
| SCHEMBL6563976 | 0.72 | KMT2A (0.52) | KMT2AMEN1POLBMAPTTP53 | |
| SCHEMBL10652013 | 0.71 | VCAM1 (0.47) | MAPTALDH1A1SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL10653026 | 0.70 | TDP1 (0.45) | KMT2AMEN1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL10566766 | 0.70 | KMT2A (0.62) | KMT2AMEN1POLBMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0197386-B1 | 2-(SUBSTITUTED SULFAMYL) DERIVATIVES OF 6-NITROBENZOIC ACID, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1988-11-02 | — | — | EP | claimed |