Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 14/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.43 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10653223 | 0.87 | PLA2G7 (0.52) | PLA2G7LMNAKDM6BKDM4AKDM4D | |
| SCHEMBL10652057 | 0.86 | PLA2G7 (0.58) | PLA2G7L3MBTL1LMNA | |
| SCHEMBL10651125 | 0.86 | LMNA (0.49) | PLA2G7LMNAKDM6BKDM4AKDM4D | |
| SCHEMBL10653116 | 0.86 | PLA2G7 (0.48) | PLA2G7LMNAKDM6BKDM4AKDM4D | |
| SCHEMBL7708557 | 0.85 | PLA2G7 (0.64) | PLA2G7LMNA | |
| SCHEMBL11456511 | 0.85 | PLA2G7 (0.48) | PLA2G7LMNAKDM6BKDM4AKDM4D | |
| SCHEMBL10735501 | 0.84 | PLA2G7 (0.66) | PLA2G7LMNAKDM6BKDM4AKDM4D | |
| SCHEMBL11450171 | 0.83 | PLA2G7 (0.55) | PLA2G7LMNA | |
| SCHEMBL10655545 | 0.83 | PLA2G7 (0.57) | PLA2G7LMNA | |
| SCHEMBL10987076 | 0.83 | PLA2G7 (0.46) | PLA2G7LMNAKDM6BKDM4AKDM4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0113572-B1 | PYRIDINE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-02-03 | — | — | EP | disclosed |
| EP-0107914-B1 | AMINOPYRIMIDINONE DERIVATIVES USEFUL AS HISTAMINE H1-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-05-14 | — | — | EP | disclosed |
| US-4547506-A | 2-Pyridylaminoakylamino-4-pyrimidones useful as histamine H1 -antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-10-15 | — | — | US | disclosed |
| US-4537891-A | 2-(3,5-Substituted-2-pyridylalkylamino)-5-benzyl-4-pyrimidones | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-08-27 | — | — | US | disclosed |
| EP-0113572-A2 | Pyridine derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-07-18 | — | — | EP | disclosed |
| EP-0107914-A1 | Aminopyrimidinone derivatives useful as histamine H1-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-05-09 | — | — | EP | disclosed |