Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 18/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.44 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.44 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7708557 | 0.87 | PLA2G7 (0.64) | PLA2G7LMNA | |
| SCHEMBL10653223 | 0.85 | PLA2G7 (0.52) | PLA2G7LMNAKDM6BKDM4AKDM4D | |
| SCHEMBL10618910 | 0.85 | PLA2G7 (0.71) | PLA2G7 | |
| SCHEMBL10652674 | 0.84 | PLA2G7 (0.62) | PLA2G7LMNAKDM6BKDM4AKDM4D | |
| SCHEMBL10652057 | 0.84 | PLA2G7 (0.58) | PLA2G7LMNA | |
| SCHEMBL10651125 | 0.84 | LMNA (0.49) | PLA2G7LMNAKDM6BKDM4AKDM4D | |
| SCHEMBL10653116 | 0.84 | PLA2G7 (0.48) | PLA2G7LMNAKDM6BKDM4AKDM4D | |
| SCHEMBL11060247 | 0.83 | PLA2G7 (0.48) | PLA2G7LMNAKDM6BKDM4AKDM4D | |
| SCHEMBL11456511 | 0.83 | PLA2G7 (0.48) | PLA2G7LMNAKDM6BKDM4AKDM4D | |
| SCHEMBL10655545 | 0.82 | PLA2G7 (0.57) | PLA2G7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4652650-A | Pyridylaminoalkylamine intermediates | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-03-24 | — | — | US | disclosed |
| US-4649141-A | HISTAMINE ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-03-10 | — | — | US | disclosed |
| US-4639519-A | 2-substituted alkylaminopyrimidones useful as H2 -antagonists and antiinflamatory agents | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-01-27 | — | — | US | disclosed |
| EP-0068833-B1 | PYRIMIDINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-10-15 | — | — | EP | disclosed |
| US-4607107-A | CHEMICAL INTERMEDIATES FOR HESTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LTD. (GB) | 1986-08-19 | — | — | US | disclosed |
| US-4584381-A | HISTAMINE H1-ANTAGONIST | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-04-22 | — | — | US | disclosed |
| US-4558128-A | ANTIHISTAMINE, ANTIINFLAMMATORY AGENT | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-12-10 | — | — | US | disclosed |
| US-4548940-A | Pyridylaminoalkylaminopyrimidones useful as histamine H1 -antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-10-22 | — | — | US | disclosed |
| US-4539207-A | Pyrimidine compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-09-03 | — | — | US | disclosed |
| EP-0049173-B1 | PYRIMIDONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL DERIVATIVES CONTAINING THEM | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-07-03 | — | — | EP | disclosed |
| US-4305945-A | Isoureas and isothioureas | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-12-15 | — | — | US | disclosed |
| EP-0003677-B1 | PYRIMIDONES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-11-11 | — | — | EP | disclosed |
| US-4234588-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-11-18 | — | — | US | disclosed |
| EP-0015138-A1 | Pyrimidone derivatives, processes for their preparation and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-09-03 | — | — | EP | disclosed |
| US-4216318-A | HISTAMINE HZ-ANTAGONISTS, ISOCYTOSINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-08-05 | — | — | US | disclosed |
| EP-0013071-A1 | Pyrimidinone derivatives, processes for preparing them and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-07-09 | — | — | EP | disclosed |
| WO-1980000966-A1 | NEW HISTAMINE H2-ANTAGONISTS | SMITH KLINE FRENCH LAB (GB) | 1980-05-15 | — | — | WO | disclosed |
| EP-0007232-A1 | Iso(thio)ureas, processes for their preparation and compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-01-23 | — | — | EP | disclosed |
| EP-0003677-A2 | Pyrimidones, processes for their preparation and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-08-22 | — | — | EP | disclosed |
| US-4154834-A | HETEROCYCLIC-(THIO)ALKYLAMINO SUBSTITUTED-4-PYRIMIDONE OR -THIONES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-05-15 | — | — | US | disclosed |