Pimagedine

Pimagedine

SCHEMBL1065359

CC(=O)O.N=C(N)NN

nearest known ligand 0.00

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Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Pimagedine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pimagedine SCHEMBL28319709 0.97 CYP1A2 (0.42)
Pimagedine SCHEMBL27623862 0.97 LMNA (0.47)
Pimagedine SCHEMBL27784772 0.87 TSHR (0.50)
Pimagedine SCHEMBL6665719 0.87 TSHR (0.50)
Pimagedine SCHEMBL9952232 0.87 TSHR (0.50)
Pimagedine SCHEMBL40128 0.87
Oxalic Acid SCHEMBL507710 0.84 TSHR (0.47)
Pimagedine SCHEMBL3279095 0.84 LMNA (0.53)
Pimagedine SCHEMBL28272894 0.84 TSHR (0.47)
Oxalic Acid SCHEMBL507712 0.84 TSHR (0.47)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118613260-A Treatment of rheumatoid arthritis 西奈克制药有限公司 2024-09-06 CN claimed
EP-4359383-A1 SALTS OF PHENYL PYRROLE AMINOGUANIDINE AND POLYMORPHS OF PHENYL PYRROLE AMINOGUANIDINIUM SALTS SynAct Pharma ApS (DK) 2024-05-01 EP claimed
CN-117836271-A Salts of phenylpyrrolaminoguanidine and polymorphs of phenylpyrrolaminoguanidine onium salts 西奈克制药有限公司 2024-04-05 CN claimed
WO-2022268814-A1 SALTS OF PHENYL PYRROLE AMINOGUANIDINE AND POLYMORPHS OF PHENYL PYRROLE AMINOGUANIDINIUM SALTS SYNACT PHARMA APS (DK) 2022-12-29 WO claimed
US-20150051328-A1 ALKYL PHOSPHINATE POLYMER AND METHODS FOR PREPARING AND USING THE SAME SHANGHAI HUIHAI CHEMICAL TECHNOLOGY CO., LTD. (CN) 2015-02-19 US claimed
US-4149980-A AMINOGUANIDINE SULFONATE OVERBASED COMPOUND STANDARD OIL COMPANY (INDIANA) (US) 1979-04-17 US claimed
US-20250032449-A1 TREATMENT OF RHEUMATOID ARTHRITIS SYNACT PHARMA APS (DK) 2025-01-30 US disclosed
EP-4440572-A1 TREATMENT OF RHEUMATOID ARTHRITIS SynAct Pharma ApS (DK) 2024-10-09 EP disclosed
CN-118613260-A Treatment of rheumatoid arthritis 西奈克制药有限公司 2024-09-06 CN disclosed
EP-4359383-A1 SALTS OF PHENYL PYRROLE AMINOGUANIDINE AND POLYMORPHS OF PHENYL PYRROLE AMINOGUANIDINIUM SALTS SynAct Pharma ApS (DK) 2024-05-01 EP disclosed
CN-117836271-A Salts of phenylpyrrolaminoguanidine and polymorphs of phenylpyrrolaminoguanidine onium salts 西奈克制药有限公司 2024-04-05 CN disclosed
WO-2023094692-A1 TREATMENT OF RHEUMATOID ARTHRITIS SYNACT PHARMA APS (DK) 2023-06-01 WO disclosed
WO-2022268814-A1 SALTS OF PHENYL PYRROLE AMINOGUANIDINE AND POLYMORPHS OF PHENYL PYRROLE AMINOGUANIDINIUM SALTS SYNACT PHARMA APS (DK) 2022-12-29 WO disclosed
CN-1085549-A Cyanophenyl-pyrazolines SCHERING AG (DE) 1994-04-20 CN disclosed
US-5140048-A Inhibitors of nonenzymatic cross-linking THE ROCKEFELLER UNIVERSITY (US) 1992-08-18 US disclosed
EP-0372603-A2 Antibacterial oral composition Colgate-Palmolive Company (US) 1990-06-13 EP disclosed
EP-0316852-A2 Inhibitors of nonenzymatic cross-linking THE ROCKEFELLER UNIVERSITY (US) 1989-05-24 EP disclosed
US-4266044-A DIACETONEACRYLAMIDE-AMINOGUANIDINE MODIFIED POLYMERS HINDER DIFFUSION OF DYES AND OR COLOR COUPLERS AGFA-GEVAERT N.V. (BE) 1981-05-05 US disclosed
US-4145220-A POLYMERS OF AMINOGUANIDINIUM SALTS OF DIACETONEACRYLAMIDE AGFA-GEVAERT, N.V. (BE) 1979-03-20 US disclosed
US-RE29168-E HEAT SENSITIVE, ANTIHALATION LAYER EASTMAN KODAK COMPANY (US) 1977-04-05 US disclosed