Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10651491 | 0.90 | LMNA (0.50) | LMNACHRM1NPSR1PIN1PIN4 | |
| SCHEMBL10654004 | 0.86 | PIN1 (0.43) | LMNACHRM1NPSR1PIN1PIN4 | |
| SCHEMBL10129654 | 0.85 | ATAD2 (0.51) | LMNANPSR1PIN1PIN4HTT | |
| SCHEMBL10650459 | 0.85 | LMNA (0.68) | LMNANPSR1PIN1PIN4HTT | |
| SCHEMBL11231189 | 0.82 | NPSR1 (0.61) | LMNANPSR1HTTUSP2ALDH1A1 | |
| SCHEMBL10508437 | 0.81 | CHRM1 (0.48) | CHRM1HTTALDH1A1KMT2AMEN1 | |
| SCHEMBL10129647 | 0.81 | PPARG (0.48) | LMNANPSR1PIN1PIN4HTT | |
| SCHEMBL10650996 | 0.78 | NPSR1 (0.70) | LMNANPSR1HTTUSP2PPARG | |
| SCHEMBL10650463 | 0.78 | HTT (0.75) | NPSR1HTTUSP2ALDH1A1KMT2A | |
| SCHEMBL4382637 | 0.78 | ATAD2 (0.65) | LMNANPSR1PIN1PIN4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4755509-A | Heterocyclic aldose reductase inhibitors and methods of using them | Carbipem (FR) | 1988-07-05 | — | — | US | disclosed |