Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.79 |
| ▸ | POLB | P06746 | 1/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | PRNP | P04156 | 1/20 | 0.69 |
| ▸ | RECQL | P46063 | 1/20 | 0.69 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SCD | O00767 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.49 |
| ▸ | PPARG | P37231 | 7/20 | 0.49 |
| ▸ | PPARD | Q03181 | 7/20 | 0.49 |
| ▸ | PPARA | Q07869 | 7/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.49 |
| ▸ | TLR2 | O60603 | 2/20 | 0.49 |
| ▸ | FABP4 | P15090 | 2/20 | 0.49 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8418103 | 0.83 | POLB (0.66) | TDP1POLBALDH1A1LMNAPRNP | |
| SCHEMBL8971941 | 0.82 | POLB (0.59) | TDP1POLBALDH1A1LMNAPRNP | |
| SCHEMBL8971725 | 0.82 | POLB (0.59) | TDP1POLBALDH1A1LMNAPRNP | |
| SCHEMBL6653369 | 0.82 | POLB (0.59) | TDP1POLBALDH1A1LMNAPRNP | |
| SCHEMBL11244780 | 0.81 | TDP1 (0.59) | TDP1POLBALDH1A1LMNAPRNP | |
| Hydrochloric Acid SCHEMBL8998499 | 0.80 | POLB (0.57) | TDP1POLBALDH1A1LMNAPRNP | |
| Hydrochloric Acid SCHEMBL8998584 | 0.80 | POLB (0.57) | TDP1POLBALDH1A1LMNAPRNP | |
| SCHEMBL846642 | 0.80 | POLB (0.56) | TDP1POLBALDH1A1LMNAPRNP | |
| SCHEMBL3176363 | 0.79 | LMNA (0.71) | TDP1POLBALDH1A1LMNAPRNP | |
| SCHEMBL12569032 | 0.79 | HSD17B3 (0.49) | TDP1POLBALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0123543-B1 | LEUKOTRIENE ANTAGONISTS, THEIR PRODUCTION AND USE AND COMPOSITIONS CONTAINING THEM | MERCK FROSST CANADA INC. (CA) | 1988-02-03 | — | — | EP | disclosed |
| US-4609744-A | 4-oxo-benzopyran carboxylic acids | MERCK FROSST CANADA INC. (CA) | 1986-09-02 | — | — | US | disclosed |
| EP-0123543-A1 | Leukotriene antagonists, their production and use and compositions containing them | MERCK FROSST CANADA INC. (CA) | 1984-10-31 | — | — | EP | disclosed |