Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10654584 | 0.91 | MAPT (0.46) | LMNAPOLBSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL2479999 | 0.90 | LMNA (0.45) | LMNAPOLBSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL29980794 | 0.89 | LMNA (0.47) | LMNAPOLBSMN1; SMN2ALDH1A1L3MBTL1 | |
| Ethylene SCHEMBL10653813 | 0.88 | MAPT (0.43) | LMNAPOLBSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL9310424 | 0.85 | MAPT (0.38) | LMNAALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL10654314 | 0.84 | MAPT (0.43) | LMNAALDH1A1L3MBTL1HPGDMAPT | |
| SCHEMBL1895618 | 0.82 | LMNA (0.43) | LMNAPOLBSMN1; SMN2KDM4EHRH2 | |
| SCHEMBL31454859 | 0.82 | ALDH1A1 (0.42) | LMNAPOLBALDH1A1L3MBTL1ATM | |
| Ethylene SCHEMBL10844325 | 0.82 | MAPT (0.41) | LMNAALDH1A1L3MBTL1HPGDMAPT | |
| SCHEMBL29574427 | 0.81 | SMN1; SMN2 (0.42) | LMNAPOLBSMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925741-A1 | PYRROLIDINE GPR40 MODULATORS | Bristol-Myers Squibb Company (US) | 2015-10-07 | — | — | EP | disclosed |
| WO-2014078609-A1 | PYRROLIDINE GPR40 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-05-22 | — | — | WO | disclosed |
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |