Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.31 |
| ▸ | HTR3B | O95264 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.31 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10653566 | 0.78 | HTR3E (0.35) | LMNASIGMAR1NPC1RAB9AAKR1C3 | |
| SCHEMBL7976910 | 0.72 | CA2 (0.47) | LMNACYP2C19 | |
| SCHEMBL3098301 | 0.67 | POLB (0.44) | AKR1C3 | |
| SCHEMBL3136272 | 0.66 | KDM4E (0.45) | LMNANPC1RAB9AHTR3EHTR3B | |
| SCHEMBL9892559 | 0.63 | MGLL (0.42) | LMNAMEN1NPC1RAB9AKMT2A | |
| SCHEMBL2466051 | 0.63 | LMNA (0.42) | LMNASIGMAR1MEN1NPC1RAB9A | |
| SCHEMBL3860610 | 0.62 | LMNA (0.39) | LMNASIGMAR1MEN1NPC1RAB9A | |
| SCHEMBL5035351 | 0.62 | LMNA (0.34) | LMNASIGMAR1MEN1NPC1RAB9A | |
| SCHEMBL1406399 | 0.62 | — | — | |
| SCHEMBL10582068 | 0.60 | LMNA (0.46) | LMNASIGMAR1MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0168309-B1 | ISOXAZOLOQUINOLINONE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1988-03-09 | — | — | EP | claimed |
| US-4588731-A | Derivatives of isoxazolo[4,5-c]quinoline(2H)-3-one and method of preparation and use as anxiolytic agents | ROUSSEL UCLAF (FR) | 1986-05-13 | — | — | US | claimed |
| EP-0168309-A1 | Isoxazoloquinolinone derivatives, process and intermediates for their preparation, use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1986-01-15 | — | — | EP | claimed |
| EP-2585443-B1 | PROCESS FOR PRODUCING IMINE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS | BASF SE (DE) | 2015-02-18 | — | — | EP | disclosed |
| EP-0168309-B1 | ISOXAZOLOQUINOLINONE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1988-03-09 | — | — | EP | disclosed |
| EP-0168309-A1 | Isoxazoloquinolinone derivatives, process and intermediates for their preparation, use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1986-01-15 | — | — | EP | disclosed |