Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.71 |
| ▸ | DRD3 | P35462 | 6/20 | 0.66 |
| ▸ | DRD1 | P21728 | 2/20 | 0.61 |
| ▸ | DRD4 | P21917 | 2/20 | 0.61 |
| ▸ | DRD5 | P21918 | 2/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10653134 | 1.00 | DRD2 (0.71) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL10653140 | 1.00 | DRD2 (0.71) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL7319920 | 0.87 | SIGMAR1 (0.69) | DRD2SIGMAR1OPRM1 | |
| Hydrochloric Acid SCHEMBL7310794 | 0.86 | SIGMAR1 (0.67) | DRD2SIGMAR1OPRM1 | |
| SCHEMBL2851870 | 0.86 | DRD2 (0.70) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL7353948 | 0.86 | DRD2 (0.86) | DRD2DRD3DRD1DRD4DRD5 | |
| Hydrochloric Acid SCHEMBL7316558 | 0.85 | DRD2 (0.84) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL7315588 | 0.85 | DRD2 (0.84) | DRD2DRD3DRD1DRD4DRD5 | |
| Hydrochloric Acid SCHEMBL10352098 | 0.85 | DRD2 (0.68) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL7199233 | 0.83 | DRD2 (0.69) | DRD2DRD3DRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175452-B1 | 1,3-DISUBSTITUTED PIPERIDINE COMPOUNDS AS NEUROLEPTIC AGENTS | PFIZER INC. (US) | 1988-09-21 | — | — | EP | disclosed |
| US-4623728-A | NERVOUS SYSTEM DISORDERS | PFIZER INC. (US) | 1986-11-18 | — | — | US | disclosed |
| US-4593037-A | Compound substituted with phenyl rings | PFIZER INC. (US) | 1986-06-03 | — | — | US | disclosed |
| EP-0175452-A1 | 1,3-Disubstituted piperidine compounds as neuroleptic agents | PFIZER INC. (US) | 1986-03-26 | — | — | EP | disclosed |