Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10660196 | 0.81 | POLB (0.49) | ALDH1A1GPR35TSHRMAPTPOLB | |
| SCHEMBL10655541 | 0.77 | HTT (0.41) | ALDH1A1TSHRMAPTPOLBMEN1 | |
| SCHEMBL10659797 | 0.69 | MAPT (0.49) | ALDH1A1GPR35TDP1TSHRMAPT | |
| SCHEMBL10657931 | 0.69 | CYP1A2 (0.45) | ALDH1A1GPR35TDP1TSHRMAPT | |
| SCHEMBL655655 | 0.68 | GPR35 (0.77) | ALDH1A1GPR35TDP1TSHRMAPT | |
| SCHEMBL2105183 | 0.67 | TSHR (0.61) | ALDH1A1GPR35TDP1TSHRMAPT | |
| SCHEMBL16244505 | 0.67 | ALDH1A1 (0.42) | ALDH1A1GPR35TDP1TSHRPOLB | |
| SCHEMBL15910567 | 0.66 | ALDH1A1 (0.49) | ALDH1A1GPR35TDP1TSHRMAPT | |
| SCHEMBL10655465 | 0.66 | RAB9A (0.48) | ALDH1A1MAPTPOLBCYP3A4MEN1 | |
| SCHEMBL8390227 | 0.66 | PDK1 (0.47) | ALDH1A1TDP1TSHRMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4745116-A | INHIBITORS OF SERINE PROTEASE | SYNTEX (U.S.A.) INC. (US) | 1988-05-17 | — | — | US | disclosed |
| US-4665070-A | SERINE PROTEINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1987-05-12 | — | — | US | disclosed |
| EP-0206323-A1 | 2-Oxy-4H-3,1-benzoxazin-4-one derivatives and related compounds | SYNTEX (U.S.A.) INC. (US) | 1986-12-30 | — | — | EP | disclosed |