Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.35 |
| ▸ | DHFR | P00374 | 5/20 | 0.34 |
| ▸ | MAOA | P21397 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10657685 | 0.88 | KDM4E (0.35) | ALDH1A1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL10657628 | 0.78 | CYP1A2 (0.35) | ALDH1A1HSD17B10KDM4EHPGDDHFR | |
| SCHEMBL9629995 | 0.76 | FEN1 (0.44) | ALDH1A1TSHR | |
| SCHEMBL10658309 | 0.74 | KDM4E (0.41) | ALDH1A1KDM4EHPGDBRD4CREBBP | |
| SCHEMBL10378739 | 0.73 | HPGD (0.38) | ALDH1A1HSD17B10HPGDTSHRLMNA | |
| SCHEMBL10657805 | 0.70 | ALDH1A1 (0.40) | ALDH1A1HSD17B10KDM4EHPGDCYP1A2 | |
| SCHEMBL10378796 | 0.67 | HPGD (0.44) | ALDH1A1KDM4EHPGDCREBBPCYP1A2 | |
| SCHEMBL10658078 | 0.67 | SMN1; SMN2 (0.34) | ALDH1A1HSD17B10KDM4ETSHRHTT | |
| SCHEMBL9629150 | 0.65 | MAPT (0.46) | ALDH1A1HPGDCYP1A2MEN1KMT2A | |
| SCHEMBL10378770 | 0.65 | PKM (0.43) | ALDH1A1CYP1A2TSHRLMNACASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |