Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 6/20 | 0.36 |
| ▸ | PPARA | Q07869 | 6/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10658293 | 0.85 | PPARA (0.42) | MAPTGPBAR1PPARGPPARAPTGS1 | |
| SCHEMBL10661841 | 0.81 | MAPT (0.41) | MAPTGPBAR1PPARGPPARAPTGS1 | |
| SCHEMBL10655898 | 0.80 | KMT2A (0.38) | MAPTGPBAR1PTGS1MEN1KMT2A | |
| SCHEMBL10657148 | 0.78 | PTGS1 (0.41) | MAPTGPBAR1PTGS1HPGDTSHR | |
| SCHEMBL10661218 | 0.75 | MAPT (0.43) | MAPTPPARGPPARAGABRA5PPARD | |
| SCHEMBL10730942 | 0.74 | PTGS1 (0.36) | GPBAR1PTGS1HPGDTSHRMAPK1 | |
| SCHEMBL10734372 | 0.74 | KMO (0.43) | MAPTGPBAR1PPARGPPARAALDH1A1 | |
| SCHEMBL10729133 | 0.73 | PTGS1 (0.36) | GPBAR1PTGS1HPGDTSHRMAPK1 | |
| SCHEMBL10661063 | 0.72 | PTGS1 (0.41) | MAPTGPBAR1PTGS1MEN1KMT2A | |
| SCHEMBL11559072 | 0.72 | PTGS1 (0.44) | MAPTGPBAR1PTGS1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4728662-A | DIURETICS, URICOSURICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-03-01 | — | — | US | disclosed |