Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 7/20 | 0.42 |
| ▸ | PPARG | P37231 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TACR3 | P29371 | 1/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10657879 | 0.85 | MAPT (0.39) | PPARAPPARGMAPTGPBAR1PTGS1 | |
| SCHEMBL10661841 | 0.84 | MAPT (0.41) | PPARAPPARGMAPTGPBAR1PTGS1 | |
| SCHEMBL10734372 | 0.81 | KMO (0.43) | PPARAPPARGMAPTGPBAR1ALDH1A1 | |
| SCHEMBL10657153 | 0.81 | HIF1A (0.42) | GPBAR1PTGS1PPARDNPSR1ALDH1A1 | |
| SCHEMBL10659627 | 0.79 | PTGS1 (0.41) | MAPTGPBAR1PTGS1NPSR1ALDH1A1 | |
| SCHEMBL10661218 | 0.76 | MAPT (0.43) | PPARAPPARGMAPTPPARDTACR3 | |
| SCHEMBL10657410 | 0.76 | MAPT (0.41) | PPARAPPARGMAPTPPARDALDH1A1 | |
| SCHEMBL10728658 | 0.75 | PLAU (0.36) | GPBAR1PTGS1 | |
| SCHEMBL10734711 | 0.74 | PTGS1 (0.35) | PPARAPPARGMAPTGPBAR1PTGS1 | |
| SCHEMBL10663368 | 0.73 | MAPT (0.45) | PPARAPPARGMAPTPPARDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4673746-A | DIURETICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1987-06-16 | — | — | US | claimed |
| US-4728662-A | DIURETICS, URICOSURICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-03-01 | — | — | US | disclosed |
| US-4673746-A | DIURETICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1987-06-16 | — | — | US | disclosed |