Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP14 | P54578 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 7/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10657180 | 0.89 | REN (0.36) | KAT2BPDE4APDE4BPDE4DALDH1A1 | |
| SCHEMBL10660843 | 0.88 | MAPT (0.39) | MAPTHPGDPDE4APDE4BPDE4D | |
| SCHEMBL10659547 | 0.88 | ALDH1A1 (0.41) | USP14MAPTHPGDKAT2BPDE4A | |
| SCHEMBL10658485 | 0.88 | HPGD (0.37) | MAPTHPGDEP300CREBBPKAT2A | |
| SCHEMBL10659134 | 0.87 | KAT2B (0.40) | MAPTEP300CREBBPKAT2AKAT2B | |
| SCHEMBL10654535 | 0.85 | PKM (0.42) | MAPTKAT2BPDE4AADORA3PDE4B | |
| SCHEMBL10377461 | 0.84 | MAPT (0.35) | MAPTHPGDPDE4APDE4BPDE4D | |
| SCHEMBL9629050 | 0.82 | HPGD (0.47) | MAPTHPGDEP300CREBBPKAT2A | |
| SCHEMBL10657014 | 0.80 | GAA (0.36) | HPGDEP300KAT2BPDE4APOLB | |
| SCHEMBL10657544 | 0.78 | EPHB4 (0.44) | MAPTKAT2BPDE4AADORA2APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |