Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CCR2 | P41597 | 4/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.43 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11599165 | 0.98 | KDM4E (0.48) | KDM4EALDH1A1TDP1CCR2CHRNA7 | |
| SCHEMBL2464746 | 0.98 | ALDH1A1 (0.47) | KDM4EALDH1A1TDP1CCR2CHRNA7 | |
| Iodide SCHEMBL9713862 | 0.96 | CHRNA7 (0.47) | KDM4EALDH1A1TDP1CCR2CHRNA7 | |
| SCHEMBL18886610 | 0.83 | KDM4E (0.47) | KDM4EALDH1A1TDP1CHRNA7CHRNB4 | |
| SCHEMBL14951079 | 0.83 | CCR2 (0.48) | CCR2 | |
| Bromide SCHEMBL11405069 | 0.81 | KDM4E (0.45) | KDM4EALDH1A1TDP1CHRNA7CHRNB4 | |
| SCHEMBL15009676 | 0.80 | CCR2 (0.63) | KDM4EALDH1A1TDP1CCR2 | |
| SCHEMBL9242506 | 0.80 | ALDH1A1 (0.44) | KDM4EALDH1A1TDP1CHRNA7CHRNB4 | |
| SCHEMBL11423047 | 0.77 | SLC18A3 (0.46) | KDM4EALDH1A1TDP1CCR2USP2 | |
| SCHEMBL8569478 | 0.76 | ALDH1A1 (0.39) | KDM4EALDH1A1TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4764670-A | Color filter arrays | EASTMAN KODAK COMPANY (US) | 1988-08-16 | — | — | US | disclosed |
| US-4110278-A | ALKALINE EARTH METAL OXIDE OR HYDROXIDE, ONIUM THICKENER | BASF AKTIENGESELLSCHAFT (DE) | 1978-08-29 | — | — | US | disclosed |
| US-4032596-A | QUATERNARY AMMONIUM SALTS, FREE RADICAL CATALYSTS | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1977-06-28 | — | — | US | disclosed |