Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.47 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2464746 | 0.98 | ALDH1A1 (0.47) | CHRNA7CHRNB4CHRNA3CHRNA10CHRNA9 | |
| Hydrochloric Acid SCHEMBL10658965 | 0.96 | KDM4E (0.50) | CHRNA7CHRNB4CHRNA3CHRNA10CHRNA9 | |
| Hydrochloric Acid SCHEMBL11599165 | 0.95 | KDM4E (0.48) | CHRNA7CHRNB4CHRNA3CHRNA10CHRNA9 | |
| SCHEMBL14951079 | 0.83 | CCR2 (0.48) | CCR2CXCR3 | |
| SCHEMBL18886610 | 0.83 | KDM4E (0.47) | CHRNA7CHRNB4CHRNA3CHRNA10CHRNA9 | |
| Bromide SCHEMBL11405069 | 0.81 | KDM4E (0.45) | CHRNA7CHRNB4CHRNA3CHRNA10CHRNA9 | |
| SCHEMBL15009676 | 0.80 | CCR2 (0.63) | KDM4EALDH1A1TDP1CCR2CXCR3 | |
| SCHEMBL9242506 | 0.80 | ALDH1A1 (0.44) | CHRNA7CHRNB4CHRNA3CHRNA10CHRNA9 | |
| SCHEMBL11423047 | 0.77 | SLC18A3 (0.46) | KDM4EALDH1A1TDP1CCR2USP2 | |
| SCHEMBL8570659 | 0.76 | ALDH1A1 (0.39) | KDM4EALDH1A1TDP1USP2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992017175-A1 | OPHTHALMIC USES OF SIGMA SITE BINDERS | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1992-10-15 | — | — | WO | disclosed |