Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10655387 | 0.87 | SMN1; SMN2 (0.44) | KDM4EALDH1A1TSHRHSD17B10BRD4 | |
| SCHEMBL10653983 | 0.84 | JAK2 (0.46) | ALDH1A1TSHRHSD17B10BRD4CREBBP | |
| SCHEMBL10654048 | 0.84 | KMT2A (0.42) | BRD4CREBBPEDNRAMEN1KMT2A | |
| SCHEMBL10657050 | 0.83 | KMT2A (0.42) | KDM4EALDH1A1TSHRHSD17B10BRD4 | |
| SCHEMBL10659689 | 0.80 | KDM4E (0.48) | KDM4EALDH1A1MAPTHTTEDNRA | |
| SCHEMBL10660831 | 0.78 | KDM4E (0.46) | KDM4EALDH1A1MAPTHTTEDNRA | |
| SCHEMBL10659019 | 0.77 | MAT2A (0.45) | BRD4CREBBPMAOB | |
| SCHEMBL10657227 | 0.77 | MAPK8 (0.48) | BRD4CREBBPMEN1KMT2ACYP1A2 | |
| SCHEMBL10654513 | 0.75 | KAT2B (0.41) | KDM4EALDH1A1TSHRHSD17B10MAPT | |
| SCHEMBL10657066 | 0.75 | MAPT (0.43) | KDM4EALDH1A1MAPTBRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |