Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
| ▸ | MPI | P34949 | 2/20 | 0.37 |
| ▸ | PHOSPHO1 | Q8TCT1 | 2/20 | 0.37 |
| ▸ | PMM2 | O15305 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | PER2 | O15055 | 4/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10659019 | 0.91 | MAT2A (0.45) | JAK2JAK3MAT2AMPIPHOSPHO1 | |
| SCHEMBL10654048 | 0.86 | KMT2A (0.42) | MAT2AMEN1KMT2ABRD4CREBBP | |
| SCHEMBL10657158 | 0.86 | HKDC1 (0.39) | MPIPHOSPHO1PMM2APOBEC3GMEN1 | |
| SCHEMBL10657050 | 0.85 | KMT2A (0.42) | MEN1ALDH1A1POLBTSHRBRCA1 | |
| SCHEMBL10659525 | 0.84 | KDM4E (0.51) | MEN1ALDH1A1TSHRKMT2AHSD17B10 | |
| SCHEMBL10657227 | 0.79 | MAPK8 (0.48) | MAT2AMEN1KMT2ABRD4CREBBP | |
| SCHEMBL10653966 | 0.77 | JAK2 (0.45) | JAK2JAK3MAT2AMPIPHOSPHO1 | |
| SCHEMBL10657066 | 0.77 | MAPT (0.43) | MPIPHOSPHO1PMM2ALDH1A1G6PD | |
| SCHEMBL10659160 | 0.76 | CREBBP (0.39) | ALDH1A1POLBKMT2AHSD17B10MAOB | |
| SCHEMBL10657423 | 0.76 | MAPT (0.41) | PHOSPHO1MEN1ALDH1A1KMT2ABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |