Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | MAT2A | P31153 | 17/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAT1A | Q00266 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10654048 | 0.91 | KMT2A (0.42) | MAPK8MAPK9MAT2APRMT5BRD4 | |
| SCHEMBL10657066 | 0.86 | MAPT (0.43) | BRD4CREBBPLMNA | |
| SCHEMBL10659019 | 0.86 | MAT2A (0.45) | MAPK8MAPK9MAT2ABRD4CREBBP | |
| SCHEMBL10657050 | 0.85 | KMT2A (0.42) | MAPK8MAPK9CYP1A2BRD4CREBBP | |
| SCHEMBL10659160 | 0.83 | CREBBP (0.39) | BRD4CREBBPLMNAKMT2A | |
| SCHEMBL10653983 | 0.79 | JAK2 (0.46) | MAT2ABRD4CREBBPMEN1KMT2A | |
| SCHEMBL10657423 | 0.78 | MAPT (0.41) | CYP1A2BRD4CREBBPMEN1KMT2A | |
| SCHEMBL10659525 | 0.77 | KDM4E (0.51) | CYP1A2BRD4CREBBPMEN1LMNA | |
| SCHEMBL10656027 | 0.77 | MAPK8 (0.51) | MAPK8MAPK9MAT2APRMT5CYP1A2 | |
| SCHEMBL10657158 | 0.76 | HKDC1 (0.39) | BRD4CREBBPMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |