Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 3/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MPI | P34949 | 2/20 | 0.37 |
| ▸ | PHOSPHO1 | Q8TCT1 | 2/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PMM2 | O15305 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10653983 | 0.91 | JAK2 (0.46) | MAT2AJAK2JAK3MPIPHOSPHO1 | |
| SCHEMBL10657227 | 0.86 | MAPK8 (0.48) | MAT2AMAPK8MAPK9BRD4CREBBP | |
| SCHEMBL10657158 | 0.86 | HKDC1 (0.39) | MPIPHOSPHO1PMM2APOBEC3GBRD4 | |
| SCHEMBL10657050 | 0.85 | KMT2A (0.42) | MAPK8MAPK9ATMBRD4CREBBP | |
| SCHEMBL10654048 | 0.79 | KMT2A (0.42) | MAT2AMAPK8MAPK9BRD4CREBBP | |
| SCHEMBL10659525 | 0.77 | KDM4E (0.51) | BRD4CREBBPMAOB | |
| SCHEMBL10655637 | 0.77 | MAT2A (0.44) | MAT2AMAPK8MAPK9JAK2JAK3 | |
| SCHEMBL10657066 | 0.77 | MAPT (0.43) | MPIPHOSPHO1G6PDPMM2BRD4 | |
| SCHEMBL10659160 | 0.76 | CREBBP (0.39) | BRD4CREBBPMAOB | |
| SCHEMBL10657423 | 0.76 | MAPT (0.41) | PHOSPHO1BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |