Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | PPARA | Q07869 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.51 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.51 |
| ▸ | ACE | P12821 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | ICMT | O60725 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10659527 | 1.00 | CA2 (0.54) | CA2PPARGPPARAMAPTKMT2A | |
| SCHEMBL10655093 | 0.85 | PPARG (0.50) | CA2PPARGPPARAKMT2AACE | |
| SCHEMBL10655084 | 0.85 | PPARG (0.50) | CA2PPARGPPARAKMT2AACE | |
| SCHEMBL714972 | 0.83 | CA2 (0.61) | CA2TAS1R3TAS1R1ALDH1A1CYP3A4 | |
| SCHEMBL9830591 | 0.83 | CA2 (0.61) | CA2TAS1R3TAS1R1ALDH1A1CYP3A4 | |
| SCHEMBL2806082 | 0.83 | ALDH1A1 (0.50) | CA2PPARGPPARAACEALDH1A1 | |
| SCHEMBL2806085 | 0.83 | ALDH1A1 (0.50) | CA2PPARGPPARAACEALDH1A1 | |
| SCHEMBL9829563 | 0.81 | CA2 (0.63) | CA2TAS1R3TAS1R1ALDH1A1CYP3A4 | |
| SCHEMBL9829566 | 0.81 | CA2 (0.63) | CA2TAS1R3TAS1R1ALDH1A1CYP3A4 | |
| SCHEMBL18979327 | 0.80 | CA2 (0.59) | CA2TAS1R3TAS1R1ACEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |