Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 6/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 6/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 6/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 7/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20878557 | 0.85 | RBP4 (0.34) | LIPE | |
| SCHEMBL3705786 | 0.79 | LIPE (0.42) | NAMPTLIPE | |
| SCHEMBL16343945 | 0.79 | LIPE (0.47) | NPC1RAB9ASMN1; SMN2LIPEKDM4E | |
| SCHEMBL12602987 | 0.78 | TAS1R3 (0.55) | TAS1R3TAS1R1TAS1R2TAAR1NAMPT | |
| SCHEMBL15956659 | 0.78 | LIPE (0.43) | LIPE | |
| SCHEMBL12602995 | 0.76 | LIPE (0.33) | LIPE | |
| SCHEMBL3720444 | 0.76 | LIPE (0.46) | NPC1RAB9ASMN1; SMN2LIPE | |
| SCHEMBL3872642 | 0.76 | LIPE (0.44) | LIPEKDM4E | |
| SCHEMBL18130771 | 0.75 | ALDH1A1 (0.42) | NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL15956897 | 0.75 | LIPE (0.43) | NPC1RAB9ASMN1; SMN2LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426109-A1 | NOVEL KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-03-07 | — | — | EP | disclosed |
| US-7943618-B2 | Btk protein kinase inhibitors | ROCHE PALO ALTO LLC (US) | 2011-05-17 | — | — | US | disclosed |
| US-20090105209-A1 | BTK protein kinase inhibitors | ROCHE PALO ALTO LLC | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105209-A1 | BTK protein kinase inhibitors | BTK, SYK, LYN | TAS1R3 1569/4885TAS1R1 858/4885TAS1R2 1507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.