Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 7/20 | 0.38 |
| ▸ | PPARG | P37231 | 5/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TACR3 | P29371 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10734372 | 0.88 | KMO (0.43) | MAPTPPARAPPARGSMN1; SMN2 | |
| SCHEMBL10661218 | 0.81 | MAPT (0.43) | MAPTPPARAPPARGTACR3GABRA5 | |
| SCHEMBL10660502 | 0.80 | PKM (0.45) | PTPN1NPC1RAB9A | |
| SCHEMBL10663535 | 0.79 | NPC1 (0.48) | MAPTSMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL10661841 | 0.77 | MAPT (0.41) | MAPTPPARAPPARGTACR3PPARD | |
| SCHEMBL10658293 | 0.73 | PPARA (0.42) | MAPTPPARAPPARGFABP4NPSR1 | |
| SCHEMBL10660005 | 0.72 | ESR1 (0.52) | MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL10843996 | 0.72 | STK17B (0.40) | NPC1RAB9A | |
| SCHEMBL10845047 | 0.71 | FFAR1 (0.37) | NPC1RAB9A | |
| SCHEMBL10646952 | 0.70 | HTT (0.41) | PPARGNPC1RAB9ATACR3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4728662-A | DIURETICS, URICOSURICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-03-01 | — | — | US | disclosed |