Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.52 |
| ▸ | PDE2A | O00408 | 2/20 | 0.52 |
| ▸ | PDE1A | P54750 | 2/20 | 0.52 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.52 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8860432 | 0.85 | POLB (0.49) | PDE3BPDE3APDE2APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL8928281 | 0.84 | POLB (0.48) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL7817348 | 0.78 | MET (0.59) | POLBMAPK1SMN1; SMN2MAPTLMNA | |
| SCHEMBL10667172 | 0.77 | CUL4A (0.57) | POLBMAPK1SMN1; SMN2MAPTMET | |
| SCHEMBL8782120 | 0.76 | ADH5 (0.51) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL18331430 | 0.76 | RAB9A (0.41) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL8928204 | 0.76 | CACNA1C (0.40) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL20279529 | 0.76 | ENPP2 (0.40) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL18331146 | 0.74 | ALDH1A1 (0.46) | POLBSMN1; SMN2MAPTLMNACYP3A4 | |
| SCHEMBL7820657 | 0.73 | KDM4E (0.61) | POLBMAPK1SMN1; SMN2MAPTMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755931-A1 | Dihydropyridine and pyridine derivatives and process for their preparation | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-01-29 | — | — | EP | claimed |
| EP-0755931-A1 | Dihydropyridine and pyridine derivatives and process for their preparation | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-01-29 | — | — | EP | disclosed |