Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 7/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.51 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27490442 | 0.74 | PNMT (0.56) | KCNJ1KCNH2SIRT6ADRB1ADRA2A | |
| Hydrochloric Acid SCHEMBL7552765 | 0.72 | PNMT (0.55) | KCNJ1KCNH2SIRT6ADRB1ADRA2A | |
| Piperazine SCHEMBL28533863 | 0.70 | ADRB1 (0.58) | KCNJ1KCNH2SIRT6ADRB1HTR7 | |
| SCHEMBL27980887 | 0.70 | SIRT6 (0.90) | KCNJ1KCNH2SIRT6ADRB1HTR7 | |
| SCHEMBL14893955 | 0.69 | KCNJ1 (0.64) | KCNJ1KCNH2SIRT6ADRB1HRH3 | |
| Azetidine SCHEMBL27897562 | 0.68 | ADRB1 (0.59) | KCNJ1KCNH2SIRT6ADRB1ADRA2A | |
| Nitrobenzene SCHEMBL28148697 | 0.68 | SIRT6 (0.56) | KCNJ1KCNH2SIRT6ADRB1HTR7 | |
| Hydrochloric Acid SCHEMBL14894292 | 0.68 | KCNJ1 (0.63) | KCNJ1KCNH2SIRT6ADRB1HRH3 | |
| SCHEMBL2723268 | 0.68 | KCNJ1 (1.00) | KCNJ1KCNH2SIRT6ADRB1HRH3 | |
| SCHEMBL1781137 | 0.68 | ADRA2A (0.49) | SIRT6ADRB1HTR7HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4730000-A | 7-SUBSTITUTED AMINO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACIDS AND ESTERS | ABBOTT LABORATORIES (US) | 1988-03-08 | — | — | US | disclosed |