SCHEMBL10667384

SCHEMBL10667384

COc1c(Cl)cc(NC(=O)N(C)C)cc1Cl

nearest known ligand 0.60

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
APEX1 P27695 1/20 0.60
TSHR P16473 1/20 0.51
TAS1R3 Q7RTX0 2/20 0.48
TAS1R1 Q7RTX1 2/20 0.48
TAS1R2 Q8TE23 2/20 0.48
KDM4E B2RXH2 1/20 0.47
ALDH1A1 P00352 1/20 0.47
GAA P10253 1/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
PKM P14618 1/20 0.42
RAB9A P51151 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11073556 0.80 ALDH1A1 (0.51) TAS1R3TAS1R1TAS1R2KDM4EALDH1A1
SCHEMBL10883879 0.80 APEX1 (0.66) APEX1TSHRKDM4EALDH1A1
SCHEMBL63260 0.79 APEX1 (0.69) APEX1TSHRALDH1A1MEN1KMT2A
SCHEMBL8536442 0.79 APEX1 (0.69) APEX1TSHRALDH1A1MEN1KMT2A
SCHEMBL29776921 0.79 APEX1 (0.69) APEX1TSHRALDH1A1MEN1KMT2A
SCHEMBL11028391 0.79 ALDH1A1 (0.50) TAS1R3TAS1R1TAS1R2KDM4EALDH1A1
SCHEMBL24899944 0.77 S1PR2 (0.68) TAS1R3TAS1R1TAS1R2KDM4EALDH1A1
SCHEMBL23169217 0.77 KMT2A (0.58) TSHRALDH1A1GAAMEN1KMT2A
SCHEMBL10756283 0.76 TAS1R3 (0.51) TAS1R3TAS1R1TAS1R2KDM4EALDH1A1
SCHEMBL7276010 0.76 TSHR (0.66) APEX1TSHRALDH1A1GAAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4789747-A BROAD LEAF PLANTS, GRASSES, WEEDS BASF AKTIENGESELLSCHAFT (DE) 1988-12-06 US disclosed
US-4761175-A M-anilido-urethanes and herbicides containing these compounds BASF AKTIENGESELLSCHAFT (DE) 1988-08-02 US disclosed
US-4744812-A HALOGENATED DIPHENYL ETHER BASF AKTIENGESELLSCHAFT (DE) 1988-05-17 US disclosed
US-4632696-A POSTEMERGENCE, PREEMERGENCE APPLICATIONS BASF AKTIENGESELLSCHAFT (DE) 1986-12-30 US disclosed
US-4568383-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1986-02-04 US disclosed
US-4523942-A 4H-3,1-Benzoxazine derivatives, compositions and herbicidal use BASF AKTIENGESELLSCHAFT (DE) 1985-06-18 US disclosed
US-4515623-A APPLYING TO PLANTS, SEEDS OR SOILS BASF AKTIENGESELLSCHAFT (DE) 1985-05-07 US disclosed
US-4505741-A Herbicides containing-3-aryl-5-methylpyrazole-4-carboxylic acid esters, their manufacture and use BASF AKTIENGESELLSCHAFT (DE) 1985-03-19 US disclosed
US-4497651-A Dichloroquinoline derivatives for use as herbicides BASF AKTIENGESELLSCHAFT (DE) 1985-02-05 US disclosed
US-4496391-A Herbicides containing 3-aryl-5-methylpyrazole-4-carboxylic acid esters, their manufacture and use BASF AKTIENGESELLSCHAFT (DE) 1985-01-29 US disclosed
US-4401821-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1983-08-30 US disclosed
US-4396418-A N-Aryl(thio)carbamates, the manufacture thereof, and the use thereof for combating unwanted plant growth BASF AKTIENGESELLSCHAFT (DE) 1983-08-02 US disclosed
US-4385924-A 1,2-Oxazolyl alkyl carbamates, and their use as herbicides BASF AKTIENGESELLSCHAFT (DE) 1983-05-31 US disclosed
US-4363651-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1982-12-14 US disclosed
US-4360672-A Substituted phenoxyphenyl pyridazones, their preparation, and their use as herbicides BASF AKTIENGESELLSCHAFT (DE) 1982-11-23 US disclosed
US-4343648-A 6H-1,2,4,6-THIATRIAZINE-1,1-DIOXIDES BASF AKTIENGESELLSCHAFT (DE) 1982-08-10 US disclosed
US-4340418-A Herbicidal agents based on N-azolylmethylacetanilides and cyclohexane-1,3-dione derivatives BASF AKTIENGESELLSCHAFT (DE) 1982-07-20 US disclosed
US-4321371-A Substituted N-benzoylanthranilic acid derivatives and their anhydro compounds BASF AKTIENGESELLSCHAFT (DE) 1982-03-23 US disclosed
US-4316014-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1982-02-16 US disclosed
US-4283547-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1981-08-11 US disclosed