SCHEMBL7276010

SCHEMBL7276010

CN(C)C(=O)Nc1cc(Cl)cc(Cl)c1

nearest known ligand 0.68

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.66
APEX1 P27695 1/20 0.59
ALDH1A1 P00352 1/20 0.49
GAA P10253 1/20 0.49
MEN1 O00255 1/20 0.48
MAPT P10636 1/20 0.48
RAB9A P51151 1/20 0.48
KMT2A Q03164 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11634512 0.86 ALDH1A1 (0.51) TSHRAPEX1ALDH1A1GAAMEN1
SCHEMBL2461958 0.81 MEN1 (0.65) TSHRAPEX1ALDH1A1GAAMEN1
SCHEMBL10883879 0.80 APEX1 (0.66) TSHRAPEX1ALDH1A1MAPT
SCHEMBL10344941 0.80 TSHR (0.56) TSHRAPEX1
Monuron SCHEMBL106717 0.79 TSHR (1.00) TSHRAPEX1ALDH1A1RAB9AL3MBTL1
Monuron SCHEMBL8539289 0.79 TSHR (1.00) TSHRAPEX1ALDH1A1RAB9AL3MBTL1
Monuron SCHEMBL9370512 0.79 TSHR (1.00) TSHRAPEX1ALDH1A1RAB9AL3MBTL1
SCHEMBL2599766 0.77 TSHR (0.52) TSHRAPEX1NPSR1
SCHEMBL10575419 0.77 LMNA (0.59) TSHRAPEX1
SCHEMBL10667384 0.76 APEX1 (0.60) TSHRAPEX1ALDH1A1GAAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-3988294-A Surface coating compositions containing antimicrobic ureas R. T. VANDERBILT COMPANY, INC. (US) 1976-10-26 US claimed
US-20180305231-A1 COMPOSITE, A METHOD OF MAKING THEREOF, AND A METHOD FOR DEGRADING A POLLUTANT KING ABDULAZIZ UNIVERSITY (SA) 2018-10-25 US disclosed
EP-0090262-B1 CERTAIN 2-(2-SUBSTITUTED BENZOYL)-1,3-CYCLOHEXANEDIONES STAUFFER CHEMICAL COMPANY (US) 1992-08-05 EP disclosed
US-4950323-A Herbicidal bis-formyl-N-aryl-N'-alkyl ureas and methods of use ICI AMERICAS INC. 1990-08-21 US disclosed
EP-0186119-B1 CERTAIN 2-(2'SUBSTITUTED BENZOYL)-1,3-CYCLOHEXANEDIONES STAUFFER CHEMICAL COMPANY (US) 1989-08-30 EP disclosed
US-4822905-A HERBICIDES STAUFFER CHEMICAL COMPANY (US) 1989-04-18 US disclosed
EP-0162336-B1 CERTAIN 2-(2-(SUBSTITUTED PHENYL)ACETYL)-1,3-CYCLOHEXANEDIONES STAUFFER CHEMICAL COMPANY (US) 1989-03-22 EP disclosed
EP-0186120-B1 CERTAIN-2-(2'-ALKYLBENZOYL)-1,3-CYCLOHEXANEDIONES STAUFFER CHEMICAL COMPANY (US) 1988-11-23 EP disclosed
EP-0135191-B1 CERTAIN 2-(2-SUBSTITUTED BENZOYL)-1,3-CYCLOHEXANEDIONES STAUFFER CHEMICAL COMPANY (US) 1988-10-26 EP disclosed
EP-0137963-B1 CERTAIN 2-(2-SUBSTITUTED BENZOYL)-1,3-CYCLOHEXANEDIONES STAUFFER CHEMICAL COMPANY (US) 1988-09-28 EP disclosed
US-4544399-A POSTEMERGENCE STAUFFER CHEMICAL COMPANY (US) 1985-10-01 US disclosed
US-4544398-A POSTEMERGENCE STAUFFER CHEMICAL COMPANY (US) 1985-10-01 US disclosed
US-4521243-A HERBICIDES STAUFFER CHEMICAL COMPANY (US) 1985-06-04 US disclosed
US-4514215-A PRE AND POSTEMERGENCE STAUFFER CHEMICAL COMPANY (US) 1985-04-30 US disclosed
EP-0137963-A1 Certain 2-(2-substituted Benzoyl)-1,3-Cyclohexanediones STAUFFER CHEMICAL COMPANY (US) 1985-04-24 EP disclosed
US-4509975-A Meta-anilide and meta-anilide urea herbicidal compounds and methods of use STAUFFER CHEMICAL COMPANY (US) 1985-04-09 US disclosed
US-4489010-A Meta-anilide and meta-anilide urea and urea salt herbicidal compounds and methods of use STAUFFER CHEMICAL COMPANY (US) 1984-12-18 US disclosed
EP-0127446-A1 Esters of 2-bromo-4-methylimidazole-5-carboxylic acid STAUFFER CHEMICAL COMPANY (US) 1984-12-05 EP disclosed
US-4482727-A Certain 1,3-cyclohexanedione adducts of substituted phenoxyphenoxypropionic acids and their use as an herbicide STAUFFER CHEMICAL COMPANY (US) 1984-11-13 US disclosed
EP-0090262-A2 Certain 2-(2-substituted benzoyl)-1,3-cyclohexanediones STAUFFER CHEMICAL COMPANY (US) 1983-10-05 EP disclosed