Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10668133 | 0.71 | — | — | |
| SCHEMBL9302170 | 0.66 | LMNA (0.36) | CYP2D6CYP2C19POLBCYP2C9KMT2A | |
| SCHEMBL7831687 | 0.64 | LMNA (0.34) | CYP2D6CYP2C19POLBCYP2C9KMT2A | |
| SCHEMBL6792682 | 0.61 | TSHR (0.45) | CYP2D6CYP2C19POLBCYP2C9KMT2A | |
| SCHEMBL2865650 | 0.61 | CYP2D6 (0.50) | CYP2D6CYP2C19POLBCYP2C9KMT2A | |
| SCHEMBL10484199 | 0.60 | KMT2A (0.46) | CYP2D6CYP2C19POLBCYP2C9KMT2A | |
| SCHEMBL29676908 | 0.59 | KDM4E (0.71) | KMT2ACA12CA9 | |
| SCHEMBL311850 | 0.59 | KDM4E (0.71) | KMT2ACA12CA9 | |
| SCHEMBL8338717 | 0.57 | — | — | |
| SCHEMBL19962102 | 0.57 | CYP2D6 (0.66) | CYP2D6CYP2C19POLBCYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4758575-A | Bi-2H-pyrroli(di)nediones | CIBA-GEIGY CORPORATION (US) | 1988-07-19 | — | — | US | disclosed |