Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831687 | 0.83 | LMNA (0.34) | LMNACYP2D6CYP2C19POLBCYP2C9 | |
| SCHEMBL10484199 | 0.75 | KMT2A (0.46) | CYP2D6CYP2C19POLBCYP2C9KMT2A | |
| Ammonia Solution, Strong SCHEMBL10668123 | 0.66 | CYP2D6 (0.33) | LMNACYP2D6CYP2C19POLBCYP2C9 | |
| SCHEMBL6792682 | 0.64 | TSHR (0.45) | LMNACYP2D6CYP2C19POLBCYP2C9 | |
| SCHEMBL4141480 | 0.61 | KMT2A (0.44) | LMNACYP2D6CYP2C19POLBCYP2C9 | |
| SCHEMBL9425191 | 0.60 | L3MBTL1 (0.51) | LMNAKMT2AKDM4EALDH1A1TDP1 | |
| SCHEMBL19962102 | 0.60 | CYP2D6 (0.66) | LMNACYP2D6CYP2C19POLBCYP2C9 | |
| SCHEMBL2865650 | 0.60 | CYP2D6 (0.50) | LMNACYP2D6CYP2C19POLBCYP2C9 | |
| SCHEMBL8338717 | 0.60 | — | — | |
| SCHEMBL10370677 | 0.59 | CYP2D6 (0.42) | LMNACYP2D6CYP2C19POLBCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0216324-B1 | 4-ALKOXY-3-PYRROLIN-2-ONE-1-YL-ACETIC ACID ALKYL AND BENZYL ESTERS AND THEIR PREPARATION | LONZA AG (CH) | 1990-11-22 | — | — | EP | claimed |
| US-5371237-A | Process for the production of 4-hydroxy-2-oxopyrrolidin-1-yl-acetamide | LONZA LTD. (CH) | 1994-12-06 | — | — | US | disclosed |
| US-5276164-A | Process for the production of 4-hydroxy-2-oxopyrrolidin-1-yl-acetamide | LONZA LTD. (CH) | 1994-01-04 | — | — | US | disclosed |