Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14349689 | 0.79 | KDM4E (0.40) | KDM4EKMT2AMAPTMAPK1HTT | |
| SCHEMBL10666827 | 0.79 | KDM4E (0.40) | KDM4EKMT2AMAPTMAPK1HTT | |
| SCHEMBL8019079 | 0.71 | KDM4E (0.51) | KDM4EMAPTNPSR1ALDH1A1TP53 | |
| SCHEMBL5656535 | 0.68 | KMT2A (0.44) | KDM4EKMT2AMAPTMAPK1HTT | |
| SCHEMBL8030043 | 0.68 | HTR6 (0.50) | KDM4EKMT2AMAPTNPSR1ALDH1A1 | |
| SCHEMBL6068564 | 0.66 | ADORA3 (0.33) | KDM4EKMT2AMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL2683475 | 0.66 | KDM4E (0.45) | KDM4EKMT2AMAPTMAPK1ALDH1A1 | |
| SCHEMBL7623370 | 0.62 | CUL4A (0.67) | KDM4EKMT2AMAPTMAPK1HTT | |
| SCHEMBL29792823 | 0.62 | DYRK1A (0.39) | RECQL | |
| SCHEMBL5909486 | 0.62 | ALDH1A1 (0.44) | KDM4EKMT2AMAPTMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4788186-A | ANXIOLYTIC AGENTS | GRUPPO LEPETIT S.P.A. (IT) | 1988-11-29 | — | — | US | disclosed |
| EP-0085840-B1 | NEW 6-SUBSTITUTED-S-TRIAZOLO(3,4-A)PHTHALAZINE DERIVATIVES | GRUPPO LEPETIT S.P.A. (IT) | 1986-10-01 | — | — | EP | disclosed |