Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.54 |
| ▸ | JUN | P05412 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | VCP | P55072 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CBS | P35520 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9679799 | 0.91 | TSHR (0.55) | TSHRNR3C1JUNNFKB1TNFSF11 | |
| SCHEMBL2335231 | 0.85 | TSHR (0.57) | TSHRNR3C1JUNNFKB1TNFSF11 | |
| SCHEMBL11673708 | 0.85 | TSHR (0.57) | TSHRNR3C1JUNNFKB1TNFSF11 | |
| SCHEMBL56335 | 0.83 | CA2 (0.48) | TSHRNR3C1ALDH1A1GAA | |
| SCHEMBL11332622 | 0.79 | TUBB4A (0.50) | TSHRNR3C1TNFSF11ALDH1A1GAA | |
| SCHEMBL10425842 | 0.78 | TSHR (0.66) | TSHRNR3C1JUNNFKB1TNFSF11 | |
| SCHEMBL23614061 | 0.78 | TNFSF11 (0.50) | TSHRNR3C1JUNNFKB1TNFSF11 | |
| SCHEMBL2729632 | 0.77 | TSHR (0.64) | TSHRNR3C1JUNNFKB1TNFSF11 | |
| SCHEMBL18052474 | 0.77 | TSHR (0.64) | TSHRNR3C1JUNNFKB1TNFSF11 | |
| SCHEMBL11347760 | 0.77 | TSHR (0.64) | TSHRNR3C1JUNNFKB1TNFSF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4785010-A | AGING RESISTANCE OF HUMANS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1988-11-15 | — | — | US | disclosed |
| EP-0124067-B1 | 2-(AMINOALKYL)-PYRROLE DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND THEIR USE | CASSELLA Aktiengesellschaft (DE) | 1986-12-17 | — | — | EP | disclosed |
| EP-0124067-A1 | 2-(Aminoalkyl)-pyrrole derivatives, process for their manufacture and their use | CASSELLA Aktiengesellschaft (DE) | 1984-11-07 | — | — | EP | disclosed |