Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.57 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.53 |
| ▸ | JUN | P05412 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.50 |
| ▸ | VCP | P55072 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | CBS | P35520 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10669643 | 0.85 | TSHR (0.58) | TSHRNR3C1JUNNFKB1PTGS1 | |
| SCHEMBL11673708 | 0.83 | TSHR (0.57) | TSHRNR3C1JUNNFKB1PTGS1 | |
| SCHEMBL30360640 | 0.82 | CA2 (0.48) | TSHRNR3C1ALDH1A1KDM4EMAPT | |
| SCHEMBL168783 | 0.82 | CA2 (0.48) | TSHRNR3C1ALDH1A1KDM4EMAPT | |
| SCHEMBL3828722 | 0.80 | CYP4F2 (0.44) | TSHRNR3C1RAB9AALDH1A1KDM4E | |
| Formic Acid SCHEMBL27768982 | 0.79 | TSHR (0.47) | TSHRPTGS1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7632890 | 0.78 | HTT (0.44) | TSHRSMN1; SMN2ALDH1A1KDM4EGAA | |
| SCHEMBL21241105 | 0.78 | LMNA (0.37) | PKMSMN1; SMN2L3MBTL1 | |
| SCHEMBL10425842 | 0.77 | TSHR (0.66) | TSHRNR3C1JUNNFKB1PTGS1 | |
| SCHEMBL23614061 | 0.77 | TNFSF11 (0.50) | TSHRNR3C1JUNNFKB1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1305015-B1 | SUBSTITUTED STYRYL BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS | UNIV TEMPLE (US) | 2013-06-12 | — | — | EP | disclosed |
| EP-2359819-A1 | Substituted styryl benzylsulfones for treating proliferative disorders | Temple University - Of The Commonwealth System of Higher Education (US) | 2011-08-24 | — | — | EP | disclosed |
| EP-2099755-A2 | ACETYLENE DERIVATIVES AS STEAROYL COA DESATURASE INHIBITORS | Glenmark Pharmaceuticals S.A. (CH) | 2009-09-16 | — | — | EP | disclosed |
| US-20080182851-A1 | ACETYLENE DERIVATIVES AS STEAROYL COA DESATURASE INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2008-07-31 | — | — | US | disclosed |
| WO-2008062276-A2 | ACETYLENE DERIVATIVES AS STEAROYL COA DESATURASE INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (US) | 2008-05-29 | — | — | WO | disclosed |
| EP-1379228-A4 | (Z)-STYRYLBENZYLSULFONES AND PHARMACEUTICAL USES THEREOF | UNIV TEMPLE (US) | 2006-01-04 | — | — | EP | disclosed |
| US-6833480-B2 | Useful in inhibiting proliferation of and/or killing cancer cells | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2004-12-21 | — | — | US | disclosed |
| US-20040133030-A1 | (Z)-styrylbenzylsulfones and pharmaceutical uses thereof | TEMPLE UNIVERSITY - OF THE COMMOWEALTH SYSTEM OF HIGHER EDUCATION | 2004-07-08 | — | — | US | disclosed |
| EP-1379228-A1 | (Z)-STYRYLBENZYLSULFONES AND PHARMACEUTICAL USES THEREOF | Temple University of the Commonwealth System of Higher Education (US) | 2004-01-14 | — | — | EP | disclosed |
| US-6642410-B2 | Useful as antiproliferative agents, including, for example, anticancer agents | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2003-11-04 | — | — | US | disclosed |
| EP-1305015-A4 | SUBSTITUTED STYRYL BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS | UNIV TEMPLE (US) | 2003-05-21 | — | — | EP | disclosed |
| EP-1305015-A1 | SUBSTITUTED STYRYL BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS | Temple University of the Commonwealth System of Higher Education (US) | 2003-05-02 | — | — | EP | disclosed |
| US-20030036536-A1 | Useful as antiproliferative agents, including, for example, anticancer agents | REDDY E PREMKUMAR (US) | 2003-02-20 | — | — | US | disclosed |
| US-6486210-B2 | SUCH AS ENANTIOMORPHS OF 4-FLUOROSTYRYL-2,3,4,5,6-PENTAFLUOROBENZYLSULFONE; ANTIPROLIFERATIVE/ANTICANCER AGENTS | Temple University—Of the Commonwealth System of Higher Education | 2002-11-26 | — | — | US | disclosed |
| WO-2002067913-A8 | (Z)-STYRYLBENZYLSULFONES AND PHARMACEUTICAL USES THEREOF | UNIV TEMPLE (US) | 2002-11-14 | — | — | WO | disclosed |
| WO-2002067913-A1 | (Z)-STYRYLBENZYLSULFONES AND PHARMACEUTICAL USES THEREOF | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2002-09-06 | — | — | WO | disclosed |
| US-20020115643-A1 | Substituted styryl benzylsulfones for treating proliferative disorders | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2002-08-22 | — | — | US | disclosed |
| WO-2001078712-A1 | SUBSTITUTED STYRYL BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2001-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040133030-A1 | (Z)-styrylbenzylsulfones and pharmaceutical uses thereof | STS, ST14, TP53 | TSHR 3442/4885NR3C1 3769/4885JUN 2518/4885 |
| US-20080182851-A1 | ACETYLENE DERIVATIVES AS STEAROYL COA DESATURASE INHIBITORS | SCD, SCD5, ACACA | TSHR 4181/4885NR3C1 2098/4885JUN 980/4885 |
| US-20030036536-A1 | Useful as antiproliferative agents, including, for example, anticancer agents | MKI67, MCL1, CCNA1 | TSHR 3468/4885NR3C1 2246/4885JUN 1790/4885 |
| US-20020115643-A1 | Substituted styryl benzylsulfones for treating proliferative disorders | HCCS, CCNO, HRAS | TSHR 604/4885NR3C1 175/4885JUN 3614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.