Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 20/20 | 0.73 |
| ▸ | EDNRA | P25101 | 20/20 | 0.73 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.50 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9369015 | 0.82 | EDNRB (0.76) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL6776490 | 0.82 | EDNRB (0.76) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL9051708 | 0.81 | EDNRB (0.75) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| Darusentan SCHEMBL1068546 | 0.81 | EDNRB (1.00) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| Darusentan SCHEMBL795084 | 0.81 | EDNRB (1.00) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL6776058 | 0.79 | EDNRB (0.71) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL12228356 | 0.79 | EDNRB (0.71) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL8115354 | 0.79 | EDNRB (0.71) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL1067548 | 0.78 | EDNRB (0.70) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL6710282 | 0.77 | EDNRB (0.68) | EDNRBEDNRANR1I2KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130317044-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | ABBOTT GMBH & CO. KG (DE) | 2013-11-28 | — | — | US | disclosed |
| US-8349843-B2 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2013-01-08 | — | — | US | disclosed |
| US-20120088911-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | ABBOTT GMBH & CO. KG (DE) | 2012-04-12 | — | — | US | disclosed |
| US-20110178294-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | ABBOTT GMBH & CO. KG (DE) | 2011-07-21 | — | — | US | disclosed |
| US-RE42477-E1 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2011-06-21 | — | — | US | disclosed |
| US-RE42462-E1 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2011-06-14 | — | — | US | disclosed |
| US-7863445-B2 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2011-01-04 | — | — | US | disclosed |
| US-20100076188-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2010-03-25 | — | — | US | disclosed |
| US-7601730-B2 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2009-10-13 | — | — | US | disclosed |
| US-7582647-B2 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2009-09-01 | — | — | US | disclosed |
| EP-1110952-B1 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO KG (DE) | 2004-09-29 | — | — | EP | disclosed |
| US-20040092742-A1 | Novel carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG | 2004-05-13 | — | — | US | disclosed |
| US-6600043-B2 | Pyramidine or triazine derivatives which specifically inhibit the binding of endothelin to the receptor | BASF AKTIENGESELLSCHAFT (DE) | 2003-07-29 | — | — | US | disclosed |
| US-20020052495-A1 | Novel carboxylic acid derivatives, their preparation and use | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2002-05-02 | — | — | US | disclosed |
| EP-0785926-B1 | CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | BASF AG (DE) | 2001-08-22 | — | — | EP | disclosed |
| EP-1110952-A1 | Carboxylic acid derivates, their preparation and use | BASF AKTIENGESELLSCHAFT (DE) | 2001-06-27 | — | — | EP | disclosed |
| US-6197958-B1 | CYCLOPENTAPYRIMIDINE DERIVATIVES; ENDOTHELIN RECEPTOR INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-03-06 | — | — | US | disclosed |
| US-6030975-A | ANTAGONIST OF ENDOTHELINS, I.E. INHIBITION OF BINDING WITH RECEPTOR; ANTITUMOR AND -CARCINOGENIC AGENTS; SIDE EFFECT REDUCTION | BASF AKTIENGESELLSCHAFT (DE) | 2000-02-29 | — | — | US | disclosed |
| US-5969134-A | CARDIOVASCULAR DISORDERS, VASOCONSTRICTION, HYPOTENSIVE AGENTS AND RELEASE OF ENDOTHELINS | BASF AKTIENGESELLSCHAFT (DE) | 1999-10-19 | — | — | US | disclosed |
| US-5932730-A | Carboxylic acid derivatives, their preparation and use | BASF AKTIENGESELLSCHAFT (DE) | 1999-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088911-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | HCAR1, HCAR2, HCAR3 | EDNRB 354/4885EDNRA 272/4885NR1I2 1229/4885 |
| US-20020052495-A1 | Novel carboxylic acid derivatives, their preparation and use | HCAR1, HCAR2, SUCNR1 | EDNRB 858/4885EDNRA 602/4885NR1I2 960/4885 |
| US-20130317044-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | HCAR1, HCAR2, HCAR3 | EDNRB 359/4885EDNRA 313/4885NR1I2 1087/4885 |
| US-20040092742-A1 | Novel carboxylic acid derivatives, their preparation and use | HCAR1, HCAR2, SUCNR1 | EDNRB 858/4885EDNRA 602/4885NR1I2 960/4885 |
| US-20100076188-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | HCAR1, HCAR2, HCAR3 | EDNRB 359/4885EDNRA 313/4885NR1I2 1087/4885 |
| US-20110178294-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | HCAR1, HCAR2, HCAR3 | EDNRB 359/4885EDNRA 313/4885NR1I2 1087/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.