Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.42 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 10/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7049085 | 0.88 | LTA4H (0.35) | LTA4HPTGS2LPAR1LPAR5FFAR1 | |
| SCHEMBL7046465 | 0.85 | ALDH1A1 (0.37) | LTA4HPTGS2FFAR1CYP3A4TSHR | |
| SCHEMBL11521654 | 0.82 | LTA4H (0.58) | LTA4HPTGS2LPAR1LPAR5FFAR1 | |
| SCHEMBL3962720 | 0.80 | LTA4H (0.51) | LTA4HPTGS2LPAR1LPAR5FFAR1 | |
| SCHEMBL7239465 | 0.79 | NCOA1 (0.42) | PTGS2CYP3A4TSHR | |
| SCHEMBL10677796 | 0.78 | CYP3A4 (0.38) | LTA4HPTGS2LPAR1LPAR5NR3C1 | |
| SCHEMBL11213243 | 0.78 | PARG (0.47) | AR | |
| SCHEMBL29812870 | 0.78 | CYP3A4 (0.40) | CYP3A4TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1071989 | 0.78 | CYP3A4 (0.40) | CYP3A4TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11198996 | 0.77 | LTA4H (0.43) | LTA4HPTGS2LPAR1LPAR5FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4766144-A | 3-carbamoyl-4-hydroxy-coumarins for combating parasitic heiminths | BAYER AKTIENGESELLSCHAFT (DE) | 1988-08-23 | — | — | US | disclosed |