Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.67 |
| ▸ | DRD2 | P14416 | 4/20 | 0.67 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.61 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.61 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.61 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.61 |
| ▸ | MGLL | Q99685 | 1/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 7/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3159332 | 0.95 | HTR1A (0.69) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL31561714 | 0.95 | HTR1A (0.69) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL17197391 | 0.91 | HTR1A (0.79) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL3268053 | 0.88 | HTR1A (0.73) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL27335815 | 0.85 | HTR1A (0.65) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL9057460 | 0.84 | HTR1A (0.79) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL20179453 | 0.84 | MGLL (0.52) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL27428981 | 0.83 | HTR1A (0.67) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL3121966 | 0.83 | HTR1A (0.67) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL9277698 | 0.83 | HTR1A (0.71) | HTR1ADRD2PTGER1PTGER4PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4761420-A | CARDIOVASCULAR DISORDERS | LABORATOIRES SYNTEX S.A. (FR) | 1988-08-02 | — | — | US | disclosed |
| EP-0249245-A2 | Antihypertensive dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1987-12-16 | — | — | EP | disclosed |