Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.69 |
| ▸ | DRD2 | P14416 | 4/20 | 0.69 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.62 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.62 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.62 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.62 |
| ▸ | MGLL | Q99685 | 1/20 | 0.58 |
| ▸ | LTA4H | P09960 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.58 |
| ▸ | ABCB1 | P08183 | 7/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31561714 | 1.00 | HTR1A (0.69) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL10683333 | 0.95 | HTR1A (0.67) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL3268053 | 0.89 | HTR1A (0.73) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL17197391 | 0.89 | HTR1A (0.79) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL9057460 | 0.86 | HTR1A (0.79) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL8409019 | 0.85 | PTGER1 (0.54) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL9277698 | 0.84 | HTR1A (0.71) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL18003392 | 0.84 | PTPRC (0.52) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL27335815 | 0.83 | HTR1A (0.65) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL4953923 | 0.83 | LTA4H (0.63) | HTR1ADRD2PTGER1PTGER4PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273745-B2 | Polycyclic acid compounds useful as CRTH2 antagonists and antiallergic agents | ASTELLAS PHARMA INC (JP) | 2012-09-25 | — | — | US | disclosed |
| WO-2012075277-A2 | SYNTHETIC METHODS | NOVOMER, INC. (US) | 2012-06-07 | — | — | WO | disclosed |
| WO-2012075277-A2 | SYNTHETIC METHODS | NOVOMER, INC. (US) | 2012-06-07 | — | — | WO | disclosed |
| CN-102442941-A | Polycyclic acid compounds useful as crth2 antagonists and antiallergic agents | ASTELLAS PHARMA INC | 2012-05-09 | — | — | CN | disclosed |
| EP-2094662-B1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC (JP) | 2012-04-11 | — | — | EP | disclosed |
| US-20100009991-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2010-01-14 | — | — | US | disclosed |
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |
| US-4835192-A | Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor | PFIZER INC. (US) | 1989-05-30 | — | — | US | disclosed |
| US-4739079-A | ANALGESICS, ANTIDIARRHEA, ANTIEMETIC AGENTS | PFIZER INC. (US) | 1988-04-19 | — | — | US | disclosed |
| US-4593131-A | Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor | PFIZER INC. (US) | 1986-06-03 | — | — | US | disclosed |
| US-4486609-A | ANALGESICS | PFIZER INC. (US) | 1984-12-04 | — | — | US | disclosed |
| EP-0049953-B1 | 4-(SUBSTITUTED PHENYL)-NAPHTHALEN-2(1H)-ONES AND 2-OLS, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER INC. (US) | 1984-05-16 | — | — | EP | disclosed |
| EP-0079168-A1 | Process for making 1-(3-benzyloxyphenyl)-1,1-dimethylheptane and intermediates therefor | PFIZER INC. (US) | 1983-05-18 | — | — | EP | disclosed |
| US-4360700-A | Intermediates for making 1-(3-benzyloxyphenyl)-1,1-dimethylheptane | PFIZER INC. (US) | 1982-11-23 | — | — | US | disclosed |
| US-4331602-A | CNS AGENTS, ANTIEMETICS, ANTIDIARRHEA | PFIZER INC. (US) | 1982-05-25 | — | — | US | disclosed |
| EP-0049953-A2 | 4-(Substituted phenyl)-naphthalen-2(1H)-ones and 2-ols, processes for their preparation, and pharmaceutical compositions containing them | PFIZER INC. (US) | 1982-04-21 | — | — | EP | disclosed |
| US-4285867-A | ANTIDIARRHEA AGENTS, ANTIEMETICS, ANALGESICS | PFIZER INC. (US) | 1981-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009991-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | HRH2, HRH1, HRH4 | HTR1A 2025/4885DRD2 621/4885PTGER1 236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.