Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.59 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.59 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.59 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1030263 | 0.82 | LMNA (0.74) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL10683525 | 0.82 | LPAR1 (0.54) | KDM4ELMNASMN1; SMN2TSHRKMT2A | |
| SCHEMBL28229350 | 0.80 | PDK1 (0.60) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL6348512 | 0.80 | PDK1 (0.72) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL10679442 | 0.79 | MAPT (0.49) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL14389906 | 0.79 | MEN1 (0.46) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL12463049 | 0.78 | MEN1 (0.54) | KDM4ELMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL28592279 | 0.78 | MEN1 (0.50) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL2226280 | 0.76 | PDK1 (0.72) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL10474698 | 0.76 | PPARA (0.61) | PDK1PDK2PDK3PDK4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252524-A2 | Aryl- and aralkylamide- derivatives of Omega- (substituted-phenyloxy)-alkanoic acids as inhibitors of acyl-coa: cholesterol acyltransferase and pharmaceuticals containing them | WARNER-LAMBERT COMPANY (US) | 1988-01-13 | — | — | EP | disclosed |