Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.72 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.72 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.72 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.72 |
| ▸ | MLYCD | O95822 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1030263 | 0.86 | LMNA (0.74) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL12368149 | 0.84 | MAPT (0.60) | PDK1PDK2PDK3PDK4MLYCD | |
| SCHEMBL23885131 | 0.84 | PDK1 (0.54) | PDK1PDK2PDK3PDK4MLYCD | |
| SCHEMBL12804315 | 0.84 | PDK1 (0.54) | PDK1PDK2PDK3PDK4MLYCD | |
| SCHEMBL30254525 | 0.84 | PDK1 (0.54) | PDK1PDK2PDK3PDK4MLYCD | |
| SCHEMBL6350417 | 0.84 | PDK1 (1.00) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL27708750 | 0.84 | PDK1 (0.53) | PDK1PDK2PDK3PDK4MLYCD | |
| SCHEMBL6348512 | 0.83 | PDK1 (0.72) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL8084614 | 0.83 | GAA (0.57) | PDK1PDK2PDK3PDK4MLYCD | |
| SCHEMBL12153170 | 0.82 | GAA (0.65) | KDM4ELMNAL3MBTL1ALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2521714-B1 | Aromatic sulfone compounds useful in the treatment of central nervous disorders | SUVEN LIFE SCIENCES LTD (IN) | 2015-08-12 | — | — | EP | disclosed |
| US-9018231-B2 | Sulfone compounds as 5-HT6 receptor ligands | SUVEN LIFE SCIENCES LIMITED (IN) | 2015-04-28 | — | — | US | disclosed |
| US-20130005709-A1 | SULFONE COMPOUNDS AS 5-HT6 RECEPTOR LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2013-01-03 | — | — | US | disclosed |
| EP-2521714-A1 | SULFONE COMPOUNDS AS 5-HT6 RECEPTOR LIGANDS | Suven Life Sciences Limited (IN) | 2012-11-14 | — | — | EP | disclosed |
| WO-2011083487-A1 | SULFONE COMPOUNDS AS 5-HT6 RECEPTOR LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2011-07-14 | — | — | WO | disclosed |
| US-7462628-B2 | Preventives/remedies for urinary disturbance | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-09 | — | — | US | disclosed |
| US-7282609-B2 | Process for production of 1-aryl-5-(trifluoromethyl)-1H-tetrazoles | TOYO KASEI KOGYO COMPANY LIMITED (JP) | 2007-10-16 | — | — | US | disclosed |
| US-20070106080-A1 | Process for production of 1-aryl-5-(trifluoromethyl)-1h-tetrazoles | TOYO KASEI KOGYO COMPANY LIMITED (JP) | 2007-05-10 | — | — | US | disclosed |
| US-7138533-B2 | Preventives/remedies for urinary disturbance | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-11-21 | — | — | US | disclosed |
| US-7132547-B2 | Preventives/remedies for urinary disturbance | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-11-07 | — | — | US | disclosed |
| US-20060211675-A1 | Preventives/remedies for urinary disturbance | ISHIHARA YUJI | 2006-09-21 | — | — | US | disclosed |
| EP-1671945-A1 | PROCESS FOR PRODUCTION OF 1-ARYL-5-(TRIFLUOROMETHYL)-1H- TETRAZOLES | Toyo Kasei Kogyo Company Limited (JP) | 2006-06-21 | — | — | EP | disclosed |
| US-20060063769-A1 | Preventives/remedies for urinary disturbance | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-03-23 | — | — | US | disclosed |
| US-20050197362-A1 | Preventives/remedies for urinary disturbance | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-09-08 | — | — | US | disclosed |
| EP-1466625-A1 | PREVENTIVES/REMEDIES FOR URINARY DISTURBANCE | Takeda Chemical Industries, Ltd. (JP) | 2004-10-13 | — | — | EP | disclosed |
| WO-1991013907-A1 | DERIVATIVES OF N-PHENYL GLYCINAMIDE, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1991-09-19 | — | — | WO | disclosed |
| US-4395559-A | ADRENERGIC BLOCKING AND HYPOTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1983-07-26 | — | — | US | disclosed |
| EP-0030380-A1 | 2,3-Indoledione derivatives, process for their preparation, intermediates, pharmaceutical compositions containing these 2,3-indoledione derivatives and their pharmaceutical use | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-06-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063769-A1 | Preventives/remedies for urinary disturbance | ACHE, BPHL, CHRM1 | PDK1 3770/4885PDK2 3100/4885PDK3 3333/4885 |
| US-20050197362-A1 | Preventives/remedies for urinary disturbance | ACHE, BPHL, CHRM1 | PDK1 3770/4885PDK2 3100/4885PDK3 3333/4885 |
| US-20070106080-A1 | Process for production of 1-aryl-5-(trifluoromethyl)-1h-tetrazoles | TH, NAT1, PAH | PDK1 3510/4885PDK2 1327/4885PDK3 2948/4885 |
| US-20060211675-A1 | Preventives/remedies for urinary disturbance | ACHE, BPHL, ACE | PDK1 4405/4885PDK2 3305/4885PDK3 3652/4885 |
| US-20130005709-A1 | SULFONE COMPOUNDS AS 5-HT6 RECEPTOR LIGANDS | HTR6, HTR5A, HTR1A | PDK1 4191/4885PDK2 3506/4885PDK3 3761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.